Abstract
Total blood flow and perfusion pressure (PP) of the internal maxillary artery (IMA) were recorded bilaterally during electrical stimulation (8 V, 2 ms) of the right cervical sympathetic nerve at frequencies (f) of 0.3, 0.5, 1.0 and 3.0 Hz in anesthetized, paralyzed and artificially ventilated dogs. Distribution of IMA-FLOW to precapillaries (CAP-FLOW) and arteriovenous anastomoses (AVA-FLOW) was determined by the tracer microspheres technique. During electrical stimulation (ES) IMA-FLOW was affected only unilaterally and decreased in a hyperbola-like fashion with the increase of f, while contralateral IMA-FLOW remained unchanged. Systemic blood pressure as well as PP of both IMA remained unchanged while heart rate was only increased during ES at maximal f. The reduction of IMA-FLOW was mainly due to marked vasoconstrictor responses of the AVAs, which were already attained at low f while significant vasoconstrictor responses of precapillaries occurred at higher f and were less pronounced. The early response of AVAs to increasing sympathetic activation enables IMA-FLOW to be adjusted in a physiological range of sympathetic activities, before CAP-FLOW is substantially reduced. The predominance of AVA-FLOW in blood flow control of the IMA was also supported by the conformity in their hyperbolic relationship with maxillary resistance at rest and during enhanced levels of sympathetic vasoconstrictor activity.
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References
Abe Y, Jackson RT (1972) The use of labeled microspheres to determine blood flow in the dog's nasal mucosa. Ann Otol Rhinol Laryngol 81:82–86
Adams DR, Hotchkiss DK (1983) The canine nasal mucosa. Zentralbl Veterinamed [C] 12:109–125
Änggård A (1974) Capillary and shunt blood flow in the nasal mucosa of the cat. Acta Otolaryngol 78:418–422
Änggård A, Lundberg JM, Lundblad L (1983) Nasal autonomic innervation with special reference to peptidergic nerves. Eur J Respir Dis 64 (suppl 128):143–148
Baker MA, Hawkins MJ, Rader RD (1982) Thermoregulatory influences on common carotid blood flow in the dog. J Appl Physiol 52:1138–1146
Bamford OS, Eccles R (1982) The central reciprocal control of nasal vasomotor oscillations. Pflügers Arch 394:139–143
Beickert P (1951) Halbseitenrhythmus der vegetativen Innervation. Arch Ohren-, Nasen-Kehlkopfheik 157:404–411
Bende M (1983) Studies of blood flow in the human nasal mucosa. Eur J Respir Dis 64 (suppl 128):400–402
Bevington PR (1969) Data reduction and error analysis for the physical sciences. McGraw-Hill, New York
Cauna N (1970) The fine structure of the arteriovenous anastomoses and its nerve supply in the human nasal respiratory mucosa. Anat Rec 168:9–22
Clairmont AA, Wright R, Dempsey E, Sheffield PA, Jackson RT (1973) Blood flow in otorhinologic tissues after histamine and papaverine. Ann Otol 82:69–74
Clara M (1956) Die arterio-venösen Anastomosen. Springer, Berlin Heidelberg New York
Dawes JDK, Prichard MM (1953) Studies of the vascular arrangements of the nose. J Anat 87:311–322
Delaney JP (1969) Arteriovenous anastomotic blood flow in the mesenteric organs. Am J Physiol 216:1556–1561
Druce HM, Bonner RF, Patow C, Choo P, Summers RJ, Kaliner MA (1984) Response of nasal blood flow to neurohormones as measured by laser-Doppler velocimetry. J Appl Physiol 57:1276–1283
Eccles R (1983) Sympathetic control of nasal erectile tissue. Eur J Respir Dis 64 (suppl 128):150–154
Eccles R, Lee RL (1981) The influence of the hypothalamus on the sympathetic innervation of the nasal vasculatur of the cat. Acta Otolaryngol 91:127–134
Goodman LS, Gilman A (1980) The pharmacological basis of therapeutics. 6th edn Macmillan, London
Hales JRS (1974) Radioactive microspheres techniques for studies of the circulation. In: Hales JRS, White SE (eds) Clinical and experimental pharmacology and physiology. Blackwell, Oxford London, pp 31–46
Hales JRS, Dampney RAL (1975) The redistribution of cardiac output in the dog during heat stress. J Therm Biol 1:29–34
Heyman MA, Payne BD, Hoffman JIE, Ruldolf AM (1977) Blood flow measurements with radionuclide-labelled particles. Prog Cardiovasc Dis 20:55–79
Keuning, J. (1968) On the nasal cycle. Int Rhinology 6:99–136
Kullmann R, Schönung W, Simon E (1970) Antagonistic changes of blood flow and sympathetic activity in different vascular beds following central thermal stimulation. I. Blood flow in skin, muscle and intestine during spinal cord heating and cooling in anaesthetized dogs. Pflügers Arch 319:146–161
Lee MC, Reid IA, Ramsay DJ (1986) Blood flows in the maxillocarotid anastomoses and internal carotid artery of conscious dogs. Anat Rec 215:192–197
Miller ME, Christensen GC, Evans HE (1964) Anatomy of the dog. Saunder, Philadelphia
Nagai M, Nagai T, Tono T (1983) Scanning electron microscopy of arteriovenous anastomosis in nasal respiratory mucosa. Acta Otolaryngol 238:115–122
Özdem C, Ercan MT (1984) Measurement of blood flow to human nasal mucosa in normal and pathological conditions by the use of the133Xe clearance technique. Arch Otorhinolaryngol 239:219–227
Olsson P, Bende M (1986) Sympathetic neurogenic control of blood flow in human nasal mucosa. Acta Otolaryngol 102:482–487
Pinakatt T, Richardson AW (1967) Distribution of cardiac output in dogs. Am J Physiol 213:905–909
Pleschka K, Langer WM, Lürkens I (1985) Bilateral compartmentalization of maxillary blood flow in the nasal and forehead regions of the dog. Fed Proc 44:4626
Pleschka K, Sommerlad U, Hashimoto M, Sugahara M, Lürkens I (1987a) Microcirculatory adjustments in the facial skin and nose of the dog during panting. Pflügers Arch 408 (suppl 1) R20, 74
Pleschka K, Sugahara M, Hashimoto M, Sommerlad U, Lürkens I, Ernst C (1987b) Local circulatory control in thermal stress. In: Dejour (ed) Comparative physiology of environmental adaptations. 2. Adaptations to extreme environments. Karger, Basel, pp 107–122
Pleschka K, Hashimoto M, Sommerlad U, Lürkens I (1987c) Distribution of facial and nasal blood flow in the cold loaded dog. J Therm Biol 12:113–117
Rossatti B (1954) Über die Blutzirkulation und die arteriovenösen Anastomosen der menschlichen Nasenschleimhaut. Anat Anz 100:243–247
Sachs L (1984) Applied statistics. Springer, Berlin Heidelberg New York
Saxena PR, Verdouw PD (1982) Redistribution by 5-hydroxytryptamine of carotid arterial blood at the expense of arteriovenous anastomotic blood flow. J Physiol 332:501–520
Vidrio H, Hong E (1976) Vascular tone and reactivity to serotonin in the internal and external carotid vascular beds of the dog. J Pharm Exp 197:49–56
Winkler B (1979) The tracer microsphere method. In: Schaper W (ed) The pathophysiology of myocardial perfusion. Elsevier, North-Holland, Amsterdam, New York, pp 13–42
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Hashimoto, M., Sommerlad, U. & Pleschka, K. Sympathetic control of blood flow to AVAs and capillaries in nasal and facial tissue supplied by the internal maxillary artery in dogs. Pflugers Arch. 410, 589–595 (1987). https://doi.org/10.1007/BF00581318
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DOI: https://doi.org/10.1007/BF00581318