Skip to main content
Log in

Toxicological certification of fatal melipramine poisoning in a child

  • Published:
Archiv für Toxikologie Aims and scope Submit manuscript

Summary

An accidental, fatal Melipramine poisoning of a child is described. The method ofGrusz for the extraction of the active ingredient from organs, various microchemical reactions and a thin-layer chromatographic technique for the identification of Melipramine are discussed. A simple method has been developed for quantitative photometric determination. The distribution of the drug in the various organs is described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Alha, A. R., V. Tamminen, A. L. Mukula, E. Levonen, A. Ruohonen u.E. Salomaa: Ultrarotspektroskopie in der gerichtschemischen Analytik. II. Mitt. Chemische Untersuchung in 4 TodesfÄllen: 1. Tofranil-Vergiftung, und kombinierte Vergiftungen, 2. Parathion und Endrin, 3. Nicotin und Parathion und 4. Pentymal, Disulfiram und Äthanol. Arch. Toxikol.18, 347 (1960).

    Google Scholar 

  • Cooper, P.: Poisoning by drugs and chemicals, vol. 129. London: Alchemist Publications, Thomas Waide and Sons Ldt. 1962.

    Google Scholar 

  • Freimuth, H. C.: Poisoning by new drugs. Report of a fatality dew suicidal ingestion of tofranil. J. forens. Sci.6, 68 (1961).

    Google Scholar 

  • Grusz-Harday, E.: Neues Verfahren zur Extraktion organischer Arzneimittel und Gifte aus Leichenteilen bei toxikologischen Analysen. Mikrochim. Acta (to be published).

  • Halasy, M., u.T. Lehoczky: Änderung der Depressionsheilung in der Neurologie [Ungarisch]. Orv. Hetil.102, 1126 (1961).

    Google Scholar 

  • Im Obersteg, J., u.J. BÄumler: Suicid mit dem Psychopharmakon Tofranil. Arch. Toxikol.19, 339 (1962).

    Google Scholar 

  • Lancaster, N. P., andA. R. Foster: Suicidal attempt by imipramine overdosage. Brit. med. J.1959II, 1458.

    Google Scholar 

  • Laves, W.: Zur Pharmakopsychologie von VerkehrsunfÄllen. Münch. med. Wschr.35, 1427 (1959).

    Google Scholar 

  • Pommé, B., J. Perrasse etJ. Girard: Intoxication volontaire aigue non mortelle par imipramine. Ann. méd.-psychol.118, 324 (1960).

    Google Scholar 

  • Pulver, R., B. Exer u.B. Herrmann: Einige Wirkungen des N-(γ-Dimethylaminopropyl)-iminodibenzyl-hydrochlorids und seiner Metabolite auf den Stoffwechsel von Neurohormonen. Arzneimittel-Forsch.10, 530 (1960).

    Google Scholar 

  • Saiz De Andrés, M.: Intoxication mortal par tofranil. Bol. inform, asoc. nac. méd. forens. (Madr.)10, 19 (1961).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Imipramine.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Faragó, A. Toxicological certification of fatal melipramine poisoning in a child. Arch. Toxikol. 21, 30–37 (1965). https://doi.org/10.1007/BF00578967

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00578967

Keywords

Navigation