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Early ontogeny of catecholaminergic structures in the sheep brain

Immunohistochemical study

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Summary

The localization of tyrosine hydroxylase was studied in the brain of sheep foetus during early ontogeny using immunohistochemistry. The first immunoreactive neurons appeared very early since they were found on day 30 of pregnancy in the medioventral part of the mesencephalic flexure. The distribution of the different catecholaminergic groups of neurons was similar to the adult's after 75 days of pregnancy. The latest group to appear was the A12 group.

Comparison of the development of the sheep foetus with rodents or primates, more commonly studied, is difficult because of its different development. It seems, however, that catecholaminergic structures appear earlier in sheep and rodents than in human. Considering the early appearance of these transmitters in the central nervous system, their role on brain development has to be studied in the future

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Abbreviations

ACTH :

adrenocorticotropin hormone

BSA :

bovine serum albumin

FLM :

fascicules longitudinales mediales

FITC :

fluorescein isothiocyanate

FSH :

follicle stimulating hormone

LH :

luteinizing hormone

LPH :

lipotropin hormone

PBS :

phosphate buffered saline

TH :

tyrosine hydroxylase

TH-IR :

tyrosine hydroxylase immunoreactive

AI :

adhesio interthalamica

BO :

bulbus olfactorius

CA :

commissura anterior

Cer :

cerebellum

cf :

cervical flexure

ChO :

chiasma opticum

CM :

corpus mamillare

COL :

colliculi

CP :

commissura posterior

Ep :

epiphysis (pineal gland)

FMT :

fasciculus mamillothalamicus

FR :

fasciculus retroflexus

Hyp :

hypophysis;mf, mesencephalic flexure

NO :

nervus opticus

P :

pons

pf :

pontic flexure;tg, tongue

I-II :

lateral ventricles

III :

third ventricle

IV :

fourth ventricle

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Authors and Affiliations

  1. Laboratoire de Neuroendocrinologie, I.N.R.A., Station de Physiologie de la Reproduction, Centre de Recherches de Tours, Monnaie, France

    Yves Tillet

  2. Laboratoire de Biochimie Cellulaire, Collège de France, Paris, France

    Jean Thibault

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  1. Yves Tillet
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  2. Jean Thibault
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Tillet, Y., Thibault, J. Early ontogeny of catecholaminergic structures in the sheep brain. Anat Embryol 177, 173–181 (1987). https://doi.org/10.1007/BF00572542

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