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Catecholaminergic Rat’s Forebrain Structures in Early Postnatal Development and Aging

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Abstract

The aim of the research was to study morphological changes that occur in cortical catecholaminergic forebrain structures of Wistar rats during postnatal development. Rat’s forebrain sections at different stages of postnatal development (postnatal day 7, postnatal day 30, 4–6 months, and 23 months) were studied using immunohistochemistry methods. It has been shown that distinct cortical areas perform a unique distribution of catecholaminergic fibers due to their functional features. Age-related changes in density of the distribution of catecholaminergic fibers were analyzed, and it has been stated that the density of catecholaminergic fibers in the sensorimotor cortex increases with aging. It has been demonstrated that confocal laser scanning microscopy offers a wide variety of opportunities for qualitative and quantitative analysis of immunohistochemical results and can be a useful tool for tyrosine hydroxylase distribution studies.

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Funding

The work was carried out within the framework of the state task of the Federal State Budgetary Scientific Institution “Institute of Experimental Medicine.”

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Authors and Affiliations

  1. Institute of Experimental Medicine, 197376, St. Petersburg, Russia

    V. A. Razenkova & D. E. Korzhevskii

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  1. V. A. Razenkova
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  2. D. E. Korzhevskii
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Contributions

V.A. Razenkova: taking material, wiring and pouring into paraffin blocks, staining preparations, photographing and analyzing preparations, statistical analysis of the obtained preparations, working with drawings, writing the text of the article. D.E. Korzhevskii: design of the experiment, work with drawings and writing the text of the article.

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Correspondence to V. A. Razenkova.

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Conflict of interest. The authors declare they have no conflicts of interest.

Statement on the welfare of animals. During the study, all applicable international, national, and institutional (conclusion no. 1/20 dated February 27, 2020, of the local ethics committee of the IEM) principles of care and use of animals were observed.

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Razenkova, V.A., Korzhevskii, D.E. Catecholaminergic Rat’s Forebrain Structures in Early Postnatal Development and Aging. Russ J Dev Biol 53, 208–216 (2022). https://doi.org/10.1134/S1062360422030067

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  • DOI: https://doi.org/10.1134/S1062360422030067

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