Stereochemical features of diterpene alkaloids in acylation and alkaline hydrolysis reactions
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Relative difficulty of saponifying an acetoxy group at C1 and ease of acylation of a hydroxy group in this position as compared with a hydroxy group C10 has been shown for alkaloids with a lycoctonine skeleton.
The anomalously easy saponification of a C1-acetoxy group in karakolidine acetates is due to the influence of the neighboring C13-hydroxy group.
KeywordsHydroxy Group Acetic Anhydride Acylation Reaction Acetoxy Group OCOC
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