Summary
The distamycin A-DAPI banding patterns of nonfluorescent, nonheterochromatic Y chromosomes (Ynf) in two patients with 45,X/46,XYnf mosaicism were investigated. In both cases moderately fluorescent bands were observed near the centromere and on the distal long arm of the Ynf. These bands were similar to the centrometric band on normal Y chromosomes and support the hypothesis that the Ynf is an isodicentric chromosome derived from the proximal portion of the Y chromosome.
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Caspersson T, Hulten M, Johasson J, Lindsten J, Thekelsen A, Zech L (1971) Translocations causing non-fluororescent Y chromosomes in human XO/XY mosaics. Hereditas 68:317–324
Curtis WR, White BJ, Lucky AW, Roche-Bender N, Knab DR, Johnsonbaugh RE (1980) Gonadal dysgenesis with mosaicism and a nonfluorescent Y chromosome: Report of two cases with correlation of clinical, pathological, and cytogenetic findings. Am J Obsetet Gynecol 136:639–645
Daniel A, Lyons N, Casey JH, Gras L (1980) Two dicentric Y isochromosomes, one without the Yqh heterochromatic segment. Hum Genet 54:31–39
Donlon TA, Magenis RE (1980) The nonfluorescent Y chromosome. Am J Hum Genet 32:68A
Fonatsch C, Flatz SD, Freymann R (1977) Nonfluorescent Y chromosome in a male infant with Turner's symptoms and XO/XY mosaicism. Clin Genet 11:235–240
Fryns JP, Pedersen JC, Goddeeris P, Van Den Berghe H (1980) Nonfluorescent Y chromosome in mixed gonadal dysgenesis with 45,X/46 XY mosaicism. Ann Genet (Paris) 23:54–56
Hsu LYF, Kim HJ, Paciuc S, Steinfeld L, Hirschhorn K (1974) Nonfluorescent and nonheterochromatic Y chromosome in 45,X/46,XY mosaicism. Ann Genet (Paris) 17:5–9
Hsu LYF, Kim HJ, Hausknecht R, Hirschhorn K (1976) Prenatal diagnosis of 45,X/46,XY mosaicism with postnatal confirmation in a phenotypically normal male infant. Clin Genet 10:232–238
Kaluzewski B, Jokinen A, Hortling H, De La Chapelle A (1978) A theory explaining the abnormality in 45,X/46,XY mosaicism with nonfluorescent Y chromosome. Presentation of three cases. Ann Genet (Paris) 21:5–11
Madan K, Gooren L, Schoemaker J (1979) Three cases of sex chromosome mosaicism with a nonfluorescent Y. Hum Genet 46:295–304
Schweizer D, Ambros P, Andrle M (1978) Modification of DAPI banding on human chromosomes by prestaining with a DNA binding of oligopeptide antibiotic, distamycin A. Exp Cell Res 111:327–332
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Wisniewski, L.P., Hirschhorn, K. Distamycin A-DAPI banding of nonfluorescent Y (Ynf) chromosomes in 45,X/46,XYnf mosaicism. Hum Genet 60, 130–132 (1982). https://doi.org/10.1007/BF00569698
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DOI: https://doi.org/10.1007/BF00569698