Abstract
Urine and organe of rats were examined for metabolites after oral dosage of thebeta-isomer of hexachlorocyclohexane (HCH).Beta-HCH was converted to 2,3,4- and 2,4,6-trichlorophenol (TCP), to other isomers of TCP, and to 2,3,4,6-tetrachlorophenol.
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References
Engst R, Macholz RM, Kujawa M (1975) Metabolismus von Lindan. Abbau von Lindan durch Schimmelpilzkulturen. Unkonjugierte Metabolite. Nahrung 18: 737–745
Engst R, Macholz RM, Kujawa M (1977) Recent state of lindane metabolism. Residue Rev 68: 59–90
Engst R, Macholz RM, Kujawa M (1979) Recent state of lindane metabolism. Part II. Residue Rev 72: 71–95
Freal JJ, Chadwick RW (1973) Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat. J Agric Food Chem 21: 424–426
Ishida M, Dahm PA (1965) Metabolism of benzene hexachloride isomers and related compounds in vitro. I. Properties and distribution of the enzyme. J Econ Entomol 58: 383–392
Koransky W, Münch G, Noack G, Portig J, Dodomann S, Wirsching M (1975) Biodegradation of alpha-Hexachlorocyclohexane. V. Characterization of the major urinary metabolites. Naunyn-Schmiedeberg's Arch Pharmacol 288: 65–78
Kurihara N (1973) Urinary metabolites from gamma- and beta-BHC in the mouse: Chlorophenol conjugates. 3rd Intern Symp Chem Toxicol. Aspects Environ Qual Tokyo (Japan): November 19–22
Macholz RM, Knoll R, Lange R (1983) Gaschromatographische Untersuchung von Hexachlor- cyclohexan- und Hexachlorbenzen-Metaboliten in wäßrigen Medien und Organen unter besonderer Berücksichtigung von Chlorphenolen. Nahrung (in press)
Macholz RM, Knoll R, Lewerenz H-J, Petrzika M, Engst R (1982) Biodegradation of alphahexachlorocyclohexane. Free metabolites in urine and organs of rats. Xenobiotica (in press)
Portig J, Kraus P, Stein K, Koransky W, Noack G, Gross B, Sodomann S (1979) Glutathione conjugate formation from hexachlorocyclohexane and pentachlorocyclohexen by rat liver in vitro. Xenobiotica 9: 353–378
Stein K (1976) Thesis, University of Marburg
Stein K, Portig J, Koransky W (1977) Oxidative transformation of hexachlorocyclohexane in rats and with rat liver microsomes. Naunyn-Schmiedeberg's Arch Pharmacol 298: 115–125
Tanaka K, Kurihara N, Nakajima N (1977) Pathways of chlorophenol formation in oxidative biodegradation of BHC. Agric Biol Chem 41: 723–725
Tanaka K, Kurihara N, Nakajima N (1979) Oxidative metabolism of lindane and its isomers with microsomes from rat liver and house fly abdomen. Pest Biochem Physiol 10: 96–103
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Macholz, R.M., Knoll, R., Lewerenz, H.J. et al. Biodegradation of beta-hexachlorocyclohexane. Arch Toxicol 50, 85–88 (1982). https://doi.org/10.1007/BF00569240
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DOI: https://doi.org/10.1007/BF00569240