Summary
We describe the results of meiotic and synaptonemal complex (SC) studies in a selected series of 45 subfertile males with different meiotic and seminal alterations. SC anomalies (pairing anomalies, fragmented SCs, or presynaptic arrest) were observed in 32 cases (71.1%). In 31% of the abnormal cases, meiotic anomalies could only be detected through the study of SCs. The origin of synaptic anomalies may be related to the assembly of myosin molecules along the chromosomes. SC analysis should become routine in the study of subfertile males.
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Chandley AC, Edmond P, Christie S, Gowans L, Fletcher J, Frackiewicz A, Newton M (1975) Cytogenetics and infertility in man. I. Karyotype and seminal analysis. Ann Hum Genet 39:231–234
Chandley AC (1979) The chromosomal basis of human infertility. Br Med Bull 35:181–186
De Martino C, Capanna E, Nicotra MR, Natali PG (1980) Immunochemical localization of contractile proteins in mammalian meiotic chromosomes. Cell Tissue Res 213:159–178
Dietrich AJJ, Mulder RJP (1981) A light microscopic study of the development and behaviour of the synaptonemal complex in spermatocytes of the mouse. Chromosoma 83:409–418
Evans EP, Breckon G, Ford CE (1964) An air drying method for meiotic preparations from mammalian testes. Cytogenetics 3:289–294
Ferguson-Smith MA (1976) Meiosis in the human male. In: Pearson PL, Lewis KR (eds) Chromosomes today, vol 5. John Wiley and Son, New York, pp 33–41
Holm PB, Rasmussen SW (1977) Three-dimensional reconstruction of meiotic chromosomes in human spermatocytes. In: Chapelle A de la, Sorsa M (eds) Chromosomes today, vol 6. Elsevier-North Holland, Amsterdam, pp 83–93
Hultén M, Eliasson R, Tillinger KG (1970) Low chiasma count and other meiotic irregularities in two infertile 46,XY men with spermatogenic arrest. Hereditas 65:285–290
Hultén M, Solari AJ, Skakkebaek NE (1974) Abnormal synaptonemal complex in an oligo-chiasmatic man with spermatogenic arrest. Hereditas 78:105–116
McIlree ME, Price WH, Court-Brown WM, Tulloch WS, Newsan JE, Maclean N (1966) Chromosome studies on testicular cells from 50 subfertile men. Lancet 2:69–71
Moses MJ, Karatsis PA, Hamilton AE (1979) Synaptonemal complex analysis of heteromorphic trivalents in Lemur hybrids. Chromosoma 70:141–160
Navarro J, Vidal F, Guitart M, Egozcue J (1981) A method for the sequential study of synaptonemal complexes by light and electron microscopy. Hum Genet 59:419–421
Pearson PL, Ellis JD, Evans JH (1970) A gross reduction in chiasma formation during meiotic prophase and a defective DNA repair mechanism associated with a case of human male infertility. Cytogenetics 9:460–467
Rasmussen SW, Holm PB (1980) Mechanics of meiosis. Hereditas 93: 187–216
Solari AJ (1980) Synaptonemal complexes and associated structures in microspread human spermatocytes. Chromosoma 81:315–337
Templado C (1981) Estudios meióticos en la infertilidad masculina (Thesis). Fac Ciencias Univ Autónoma Barcelona
Templado C, Marina S, Egozcue J (1976) Three cases of low chiasma frequency associated with infertility in man. Andrologia 8:285–289
Templado C, Marina S, Suarez Canal F, Gil-Vernet E, Izquierdo L, Egozcue J (1978) Four cases of low chiasma frequency diagnosed in semen. Int J Androl 1:153–161
Templado C, Marina S, Coll MD, Egozcue J (1980) Meiotic studies in human semen. Report of 180 cases. Hum Genet 53:335–339
Templado C, Vidal F, Marina S, Pomerol JM, Egozcue J (1981) A new meiotic mutation: desynapsis of individual bivalents. Hum Genet 59:345–348
Vidal F, Templado C, Navarro J, Marina S, Egozcue J (1982) Meiotic and synaptonemal complex studies in a 14/21 translocation carrier. Int J Androl 5:21–26
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Vidal, F., Templado, C., Navarro, J. et al. Meiotic and synaptonemal complex studies in 45 subfertile males. Hum Genet 60, 301–304 (1982). https://doi.org/10.1007/BF00569207
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DOI: https://doi.org/10.1007/BF00569207