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Features of the inhibition of transport Na+, K+-ATPase by cardenolide bisglycosides

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Summary

Bisglycosides of strophanthidol and strophanthidin obtained by partial synthesis behave differently with respect to Na+,K+-ATPase. Strophanthidol 3,19-bisrhamnoside does not possess the biological activity characteristic for cardiac glycosides. Strophanthidin 3,5-bisrhamnoside and compounds similar to it that are glycosylated at the C-5 hydroxyl possess a reduced capacity for inhibition.

A two-center model of the digitalis receptor is put forward which explains the cause of the different activities of cardenolide glycosides differing from one another by structural elements in the steroid part of the molecule or of the sugar component.

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Literature cited

  1. R. Thomas, J. Boutagy, and A. Gelbert, J. Pharm. Sci.,11, 1649 (1974).

    Google Scholar 

  2. R. Petersen, H. Flasch, and N. Heinz, Arzneim.-Forsch./Drug Res.,27, (I), 642 (1977).

    Google Scholar 

  3. N. M. Mirsalikhova, F. T. Umarova, N. Sh. Pal'yants, and N. K. Abubakirov, Khim. Prirodn. Soedin., 188 (1976).

  4. A. Jaunin, H. P. Weber, and A. Wartburg, Helv. Chim. Acta,56, 2117 (1973).

    Google Scholar 

  5. N. Sh. Pal'yants, M. B. Gorovits, and N. K. Abubakirov, Khim. Prirodn. Soedin., 765 (1976).

  6. N. Sh. Pal'yants and N. K. Abubakirov, Khim. Prirodn. Soedin., 125 (1977).

  7. V. T. Chernobai, Zh. Obshch. Khim.,34, 1690, 3852 (1964).

    Google Scholar 

  8. K. Repke, Proceedings of the Second International Pharmacological Meeting, 1963, Vol. 4, Prague, Czechoslovakia (1965), p. 65; Pharmazie,27, 693 (1972).

    Google Scholar 

  9. J. Fried, R. G. Linville, and R. C. Elderfield, J. Org. Chem.,7, 362 (1942).

    Google Scholar 

  10. L. Ruzicka, T. Reichstein, and A. Fürst, Helv. Chim. Acta.,24, 76 (1941).

    Google Scholar 

  11. J. C. Skou, Biochem. Biophys. Acta,58, 314 (1962).

    Google Scholar 

  12. Ya. Kh. Turakulov, L. I. Kurgul'tseva, and A. I. Gagel'gans, Biokhimiya,32, 106 (1967).

    Google Scholar 

  13. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. I. Randall, J. Biol. Chem.,193, 265 (1951).

    Google Scholar 

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Authors
  1. N. M. Mirsalikhova
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  2. N. Sh. Pal'yants
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  3. N. K. Abubakirov
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Additional information

Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 95–102, January–February, 1978.

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Mirsalikhova, N.M., Pal'yants, N.S. & Abubakirov, N.K. Features of the inhibition of transport Na+, K+-ATPase by cardenolide bisglycosides. Chem Nat Compd 14, 76–81 (1978). https://doi.org/10.1007/BF00565882

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  • DOI: https://doi.org/10.1007/BF00565882

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