Summary
The Syrian hamster ear model was used to study effects of the anti-androgen cyproterone acetate and of the anti-lipogenic compound 17β-carboxylic acid methyl ester and its ethyl ester. The steroid derivatives were applied topically in a 1–2% concentration or given systemically. Response of sebaceous gland was measured by means of cell proliferation (3H-TdR autoradiography) and by gland size (histoplanimetry).
Cyproterone acetate significantly reduced the labelling and the planimetric value, both topically and systemically.
The carboxylic acid derivatives, which block the 5α-reductase were ineffective.
The new animal model is a sensitive and suitable means to study inhibition of sebum production.
Zusammenfassung
Am Ohrmodell des syrischen Hamsters wurden die Wirkungen des Antiandrogens Cyproteronacetat und der die Lipogenese hemmenden Substanzen 17β-Carboxylsäuremethylester und 17β-Carboxylsäureäthylester (Blockierung der 5α-Reductase) untersucht. Die Steroidderivate wurden in 1–2%iger Konzentration topisch oder systemisch appliziert. Als funktionelle Meßdaten der Zellproliferation dienten der Markierungsindex (3H-Thymidin, 45 min) und die histoplanimetrisch bestimmte Talgdrüsenfläche.
Topisch und systemisch verabreichtes Cyproteronacetat reduzierte signifikant den Markierungsindex und die Talgdrüsenflächen. Die Carboxylsäurederivate zeigten keinen Effekt.
Das neue Tiermodell des syrischen Hamsters ist empfindlich und geeignet, Fragen der Talgproduktion zu studieren.
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Kindly supported by the Deutsche Forschungsgemeinschaft, grant Pl 58/4
In part presented at the annual meeting of the Arbeitsgemeinschaft für Dermatologische Forschung (ADF), 22–23 November 1975, Berlin
We acknowledge the technical assistance of Mrs. A. Endell
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Luderschmidt, C., Plewig, G. Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Arch. Derm. Res. 258, 185–191 (1977). https://doi.org/10.1007/BF00561624
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DOI: https://doi.org/10.1007/BF00561624