Abstract
All four possible isomers of 4-ureido-3-hydroxy-2-(5′-alkoxycarbonylbutyl)-thiophan were synthesized by the action of potassium isocyanate on the corresponding hydrochlorides (or hydrobromides) of the stereoisomers of A-amino-3-hydroxy-2[5′-methoxy (or ethoxy)carbonylbutyl]thiophans, which were obtained by several methods. The configurations of the compounds obtained were proved by PMR spectroscopy.
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S. D. Mikhno, T. M. Filippova, N. S. Kulachkina, T. N. Polyanskaya, I. M. Kustanovich, and V. M. Berezovskii, Khim. Geterotsikl. Soedin., No. 7, 897 (1972).
S. D. Mikhno, T. M. Filippova, N. S. Kulachkina, I. G. Suchkova, and V. M. Berezovskii, Khim. Geterotsikl. Soedin., No. 3, 331 (1976).
S. D. Mikhno, T. M. Filippova, N. S. Kulachkina, I. G. Suchkova, and V. M. Berezovskii, Khim. Geterotsikl. Soedin., No. 4, 459 (1976).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 616–620, May, 1980
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Mikhno, S.D., Filippova, T.M., Kulachkina, N.S. et al. Stereospecific synthesis of all of the possible isomers of 4-ureido-3-hydroxy-2-(5′-alkoxycarbonylbutyl)thiophan. Chem Heterocycl Compd 16, 474–478 (1980). https://doi.org/10.1007/BF00561343
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DOI: https://doi.org/10.1007/BF00561343