Summary
The metabolism of orally administered procainamide has been studied in fast and slow acetylators of sulphadimidine. Although the overall excretion in 6 hours of procainamide and its metabolites was similar in both groups, the excretion ofn-acetylprocainamide by the fast acetylator group was much higher (40.9 mg vs 14.9 mg); individual values showed a bimodal distribution. In contrast, no difference between the two groups in totaln-acetyl-p-aminobenzoic acid was detected, the percentages ofn-acetyl-PABA being distributed unimodally. The plasma half-life of procainamide was shorter in the fast acetylator group (2.2 hr vs 3.9 hr).
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Du Souich, P., Erill, S. Patterns of acetylation of procainamide and procainamide-derived p-aminobenzoic acid in man. Eur J Clin Pharmacol 10, 283–287 (1976). https://doi.org/10.1007/BF00558341
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DOI: https://doi.org/10.1007/BF00558341