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Absence of leukocyte-migration inhibitory factor in serum from patients with mycosis fungoides

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Summary

Sera from 16 patients with mycosis fungoides at various stages of the disease were investigated for the presence of a leukocyte-migration inhibitory factor. The agarose gel technique with human peripheral blood leukocytes as migrating indicator cells was used for the purpose. The migration inhibitory effect of patients sera, pooled AB-sera and sera from control persons was tested on peripheral blood leukocytes from patients and controls. Also upconcentrated sera were used.

The presence of substances with migration inhibitory effect in serum from patients with mycosis fungoides could not be demonstrated. The significance of these findings is discussed.

Zusammenfassung

Das Serum von 16 Patienten mit Mykosis fungoides in verschiedenen Entwicklungsstadien wurde auf das Vorliegen des Leukocytenmigrations-Inhibitor-Faktors untersucht. Die Agarose-Gel-Technik mit menschlichen Leukocyten aus dem Blut als Indikatorzelle wurde methodisch verwandt. Der Leukocyten-migrationshemmende Effekt von AB-Sera und Sera von Kontrollpersonen wurd an peripheren Blutleukocyten der Patienten und Kontrollen getestet. Höher konzentrierte Sera wurden ebenfalls verwandt.

Im Serum von Patienten mit Mykosis fungoides konnten keine Substanzen aufgefunden werden, die einen Leukocyten-migrationshemmenden Effekt besaßen.

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Authors and Affiliations

  1. Department of Dermatology and Venerology, Marselisborg Hospital, University of Aarhus, DK-8000, Aarhus, Denmark

    Henning Thulin

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  1. Henning Thulin
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This work was supported by a grant from the P. Carl Petersens Foundation

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Thulin, H. Absence of leukocyte-migration inhibitory factor in serum from patients with mycosis fungoides. Arch. Derm. Res. 257, 157–161 (1976). https://doi.org/10.1007/BF00558089

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  • DOI: https://doi.org/10.1007/BF00558089

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