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Veränderungen an der glomerulären Basalmembran des Meerschweinchens durch Fremdinsulin und ihre Beziehung zur Höhe der Insulin-Bindungsfähigkeit des Serums

Changes at the basement membrane of the glomerulus of the guinea pig caused by foreign insulin; their relation to size of insulin-binding-capacity of serum

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Summary

In experiments with insulin-immunized guinea pigs deposits could be observed, on the epithelial side of the glomerular basement membrane that were directly related to the height of insulin antibody titer. These deposits resembled the “humps”, that have been assumed to be pathognomonic for acute diffuse poststreptococcal glomerulonephritis.

Zusammenfassung

In Experimenten mit insulinimmunisierten Meerschweinchen wurden an der epithelialen Seite der glomerulären Basalmembran Depots beobachtet, die in deutlich erkennbarer Abhängigkeit zur Höhe des Insulinantikörpertiters standen. Diese Depots, die den „humps“ ähnlich sind, welche als pathognomonisch für die akute diffuse Poststreptokokkenglomerulonephritis gelten, werden für Antigen-Antikörperkomplexe gehalten.

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Authors and Affiliations

  1. Pathologisches Institute der Universität Tübingen, Germany

    H. Wehner, U. Schade & F. Asante

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  1. H. Wehner
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  2. U. Schade
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  3. F. Asante
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Additional information

Mit Unterstützung der Deutschen Forschungsgemeinschaft. Mit technischer Assistenz von Fräulein S. Helber und Fräulein U. Lendzian.

Nach einem Vortrag auf dem Gemeinsamen Symposion der deutschsprachigen und französisch sprechenden Gesellschaften für Nephrologie in Straßburg (Frankreich) 1969.

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Wehner, H., Schade, U. & Asante, F. Veränderungen an der glomerulären Basalmembran des Meerschweinchens durch Fremdinsulin und ihre Beziehung zur Höhe der Insulin-Bindungsfähigkeit des Serums. Virchows Arch. Abt. A Path. Anat. 348, 164–169 (1969). https://doi.org/10.1007/BF00544323

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  • DOI: https://doi.org/10.1007/BF00544323

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