Summary
It has been recently noted that dipyridamole (DP) may be involved in certain immunological reactions, in addition to its antiplatelet action. In the present investigation the mitogenic response of human lymphocytes from three groups of subjects to 3 different lectins was examined. In both the experimental group treated over a short period and in the controls a highly significant decrease in the mean lymphocyte response to all 3 mitogens was noted following 3 days of DP administration. The response remained low after an additional 3 days of treatment. Discontinuation of drug administration was followed by a significant increase in response to two mitogens, concanavalin A (Con A) and pokeweed mitogen (PWM). The response to phytohaemagglutinin (PHA) extent only increased to a small, non-significant. No change in the mean mitogenic response was detected in the group undergoing long-term treatment. The mechanism by which DP alters lymphocyte activity is as yet unknown.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mehta J, Mehta P, Pepine CR (1981) Platelet function studies in coronary artery disease-effect of dipyridamole. Am J Cardiol 47: 1111–1113
Lindeman D (1977) Drug treatment of the chronic idiopathic glomerulopathies. Postgrad Med 62: 135–143
Kauffmann HM (1980) Platelet inhibitors in human renal homotransplantation. Randomized comparison of aspirin versus dipyridamole. Transplant Proc 12: 311–314
Gurewich V, Lipinski B, Wetmore R (1975) Inhibition of intravascular fibrin deposition by dipyridamole in experimental animals. Blood 45: 569–575
Coeugniet E (1978) Thrombocyte migration inhibitory activity of human lymphocytes stimulated with concanavaline-A antagonized by dipyridamole and acetylsalicylin acid. Thromb Haemostas 39: 528–529
Amir J, Krauss S (1973) Treatment of thrombotic thrombocytopenic purpura with antiplatelet drug. Blood 42: 27–33
Chassin MM, Cirgus MA, Johns DG, Adamson RH (1977) Adenosine deaminase inhibition for immunosuppression. N Engl J Med 296: 1232–1233
Allison AC, Hovi T, Watts RW, Webster AD (1977) Ciba Found Symp 48: 207–221
Tanner MJA, Boxer DM (1974) A set of surface proteins common to circulating human platelet and lymphocyte. Biochem J 141: 909–911
Coeugniet EG, Søeberg B (1975) Letter dipyridamole: increase of human leucocytes migration in agarose and modification of human lymphocyte activity. Thromb Diath Haemorrh 33: 664–665
Pazdur J, Krzysztof K, Kopek M (1980) Effects of dipyridamole on human blood lymphocytes. Biochem Pharmacol 29: 2515–2517
Taniguchi N, Miyawaki T, Muriya N (1977) Mitogenic responsiveness and monocyte lymphocyte interaction of early and late rosette forming cell population of human peripheral blood lymphocytes. J Immunol 118: 193–197
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Melamed, I., Aviram, A., Rubinstein, A. et al. Inhibition of lymphocyte response to mitogens by dipyridamole: Preliminary findings. Eur J Clin Pharmacol 28, 263–265 (1985). https://doi.org/10.1007/BF00543321
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00543321