Summary
Fragments of synovial membranes from three patients with rheumatoid arthritis were incubated in Dulbecco's modified Eagle's medium (DMEM). Histamine was released into the medium at rates up to 649.3 ng/g synovium/day. To investigate whether histamine in synovial fluid may have more than a vasoactive role, cells cultured from human trabecular bone adjacent to a rheumatoid joint and human adherent rheumatoid synovial cells were incubated with different concentrations of histamine for 5 min. Histamine increased the intracellular content of cyclic AMP up to three fold in a dose-related manner but had no effect on synovial cells. This offers preliminary evidence that cells grown from human trabecular bone have histamine receptors.
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References
Bromley M, Fisher WD, Woolley DE (1984) Mast cells at sites of cartilage erosion in the rheumatoid joint. Ann Rheum Dis 43:76–79
Crisp AJ, Chapman CM, Kirkham SF, Schiller AL, Krane SM (in press) Articular mastocytosis in rheumatoid arthritis. Arthritis Rheum
Riley JF (1963) Functional significance of histamine and heparin in tissue mast cells. Ann NY Acad Sci 103:151–163
Partsch G, Schwagerl W, Eberl R (1982) Histamine in rheumatic diseases. Z Rheumatol 41:19–22
Taylor DJ, Yoffe JR, Woolley DE (1983) Histamine H2 receptors on fetal-bovine articular chondrocytes. Biochem J 212:517–520
Norton LA, Proffitt WR, Moore RR (1969) Inhibition of bone growth in vitro by endotoxin: histamine effect. Nature 221:469–471
Siraganian RP (1974) An automated continuous flow system for the extraction and fluorimetric analysis of histamine. Anal Biochem 57:383–394
Dayer JM, Krane SM, Russell RGG, Robinson DR (1976) Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. PNAS 73:945–949
Beresford JN, MacDonald BR, Gowen M, Couch M, Aked D, Sharpe PT, Gallagher JA, Poser JW, Russell RGG (1983) Further characteristics of a system for the culture of human bone cells. Calcif Tissue Int 35:637
Wergedal JE, Baylink DJ (1969) Distribution of acid and alkaline phosphatase activity in undemineralised sections of the rat diaphysis. J Histochem Cytochem 17:799–806
Marquandt DL, Parker CW, Sullivan TJ (1978) Potentiation of mast cell mediator release by adenosine. J Immunol 120:871–878
Grennan DM, Rooney PJ, Onge RA, Brooks PM, Zeitlin IJ, Dick WC (1975) Histamine receptors in the synovial microcirculation. Eur J Clin Invest 5:75–82
Horwitz R, Schachter M (1983) Carcinoid arthropathy-radiological features. Br J Radiol 56:131–132
Pickup ME, Dixon JS, Lowe JR, Wright V (1980) Serum histidine in rheumatoid arthritis: changes induced by antirheumatic drug therapy. J Rheumatol 7:71–76
Permin H, Stahl Skov P, Norn S, Geisler A, Klysner R, Andersen V, Wiik A, Manthorpe R, Nielsen H, Petersen J (1981) Possible role of histamine in rheumatoid arthritis. Allergy 36:435–436
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Crisp, A.J. Studies of histamine in the rheumatoid joint. Rheumatol Int 4, 125–128 (1984). https://doi.org/10.1007/BF00541181
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DOI: https://doi.org/10.1007/BF00541181