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Investigation of serum LDH and its isoenzymatic model in carbon disulphide polyneuritis

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Summary

Serum LDH and its isoenzymatic model was determined in 20 in-patients with carbon disulphide poisoning.

56% out of 16 patients who had also a toxic polyneuritis showed an anodic accentuation of the isoenzymatic model. The increase of the serum fraction LDH1 found by authors was attributed to the toxic lesion of the peripheral neuron.

The investigation of serum LDH and its isoenzymatic model in carbon disulphide polyneuritis was intended to provide more details concerning the metabolic disturbances occurring in this severe form of carbon disulphide poisoning.

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References

  • Cohen, A. E., Scheel, L. D., Kopp, J. F., Stockell, F. R., Keenan, J. B. S., Mountain, J. T., Paulus, H. J.: Biochemical mechanism in chronic carbon disulphide poisoning. Ind. Hyg. 20 (1959).

  • Scheel, L. D.: Experimental carbon disulphide poisoning in rabbits. Its mechanism and similarities with human case reports. Toxicology of carbon disulphide. Excerpta med. Monogr. 107 (1966).

  • Vertin, P. G.: Biochemical and clinical studies of the pathophysiology of carbon disulphide. Toxicology of carbon disulphide. Excerpta med. Monogr. 94 (1966).

  • Zamfirescu-Gheorghiu, M., Serban, M., VlĂdescu, C., Chivulescu, Z.: Organospecificity of lactic dehydrogenase izoenzyme, their relationship with the energetic pattern and tissular differentiation. Rev. roum. méd. interne 4, 6 (1967).

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Authors and Affiliations

  1. Clinic of Occupational Diseases, Hospital Colentina, Bucharest, Romania

    P. Manu, Ioana Lancranjan & Marcela Zamfirescu

  2. Institute of Internal Medicine, Bucharest, Romania

    P. Manu, Ioana Lancranjan & Marcela Zamfirescu

Authors
  1. P. Manu
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  2. Ioana Lancranjan
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  3. Marcela Zamfirescu
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Manu, P., Lancranjan, I. & Zamfirescu, M. Investigation of serum LDH and its isoenzymatic model in carbon disulphide polyneuritis. Int. Arch. Arbeitsmed 26, 45–49 (1970). https://doi.org/10.1007/BF00539233

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  • DOI: https://doi.org/10.1007/BF00539233

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