Abstract
Acute phase serum (APS) given at the time of challenge with Plasmodium berghei inhibited the generation to immunity to the infecting plasmodia. Administered with a single dose of vaccine, it inhibited induction of immunity by the vaccine. Three weekly doses, the last given two weeks before infection, induced immunity. Administration of vaccine simultaneously with infection neither aggravated nor ameliorated the infection. These results indicate that the effect of administration of APS on immunity generated by immunization or infection is dose- and time-dependent. The depression of immunity induced by this serum is thus temporary, the host finally overcoming the depression and responding to the plasmodial antigen in the serum. The interaction of vaccine and infection observed indicates that the introduction of vaccine is not detrimental to the individual incubating infection; rather, the vaccine is rendered useless, the reducing the aggregate benefit of the immunization to the group.
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References
Alder JD, Kreier JP (1984) Effects of immune complexes on immunity to P. berghei infections. Trop Med Parasitol 35:253–259
Anderson RM, May RM (1985) Vaccination and herd immunity to infectious diseases. Nature 318:323–329
Brown KM, Kreier JP (1982) Plasmodium berghei malaria: blockage by immune complexes of macrophage receptors for opsonized plasmodia. Infect Immun 37:1227–1233
Brown KM, Kreier JP (1986) Effect of macrophage activation on phagocytoplasmodium interaction. Infect Immun 51:744–749
Collins WE, Contacos PG, Harrison AJ, Stanfill PS, Skinner JC (1977) Attempts to immunize monkeys against Plasmodium knowlesi by using heat stable serum soluble antigens. Am J Trop Med Hyg 26:373–376
Cox HW, Hayes MM, Saleh SM (1983) Immune complexes and immunoconglutinin interactions associated with altered lymphocyte activity in Plasmodium chabaudi infections. J Parasitol 69:809–813
Gabrielsen AA Jr, Jensen JB (1982) Mitogenic activity of extracts from continuous cultures of Plasmodium falciparum. Am J Trop Med Hyg 31:441–448
Goumard P, VuDac N, Maurios P, Camus D (1982) Influence of malaria on a pre-existing antibody response to heterologous antigens. Ann Inst Pasteur Immunol 1330:313–326
Grothaus GD, Kreier JP (1980) Isolation of a soluble component of Plasmodium berghei which induces immunity in rats. Infect Immun 28:245–253
Kreier JP, Green T (1980) The vertebrate hosts immunological response to plasmodia. In: Kreier JP (ed) Malaria. Academic Press, New York, pp 111–162
Mims CA (1982) The pathogenesis of infectious disease. Academic Press, London
Murphy GE, Swift HF (1949) Induction of cardiac lesions closely resembling those of rheumatic fever in rabbits following repeated skin infections with group A streptococci. J Exp Med 89:687–698
Murphy JR, Lefford MJ (1979) Host defense in murine malaria: Successful vaccination of mice against Plasmodium berghei by using formolinized blood parasites. Am J Trop Med Hyg 28:4–11
Packer B, Kreier JP (1986) Plasmodium berghei malaria: Effects of acute phase serum and erythrocyte-bound immunoglobulin on erythrophagocytosis by rat peritoneal macrophages. Infect Immun 51:141–146
Park WH, Schroder MC (1932) Diphtheria toxin-antitoxin and toxoid. A comparison. Am J Public Health 22:7–16
Prior R, Kreier JP (1972a) Plasmodium berghei freed from host erythrocytes by a continuous-flow ultrasonic system. Exp Parasitol 32:239–243
Prior R, Kreier JP (1972b) Isolation of Plasmodium berghei by use of a continuous-flow system: A morphological and immunological evaluation. Proc Helminthol Soc Washington 29:563–574
Saul KW, Kreier JP (1977) Immunization of rats with antigens from a population of free parasites rich in merozoites. Trop Med Parasitol 28:302–318
Shear HL, Nussenzweig RS, Bianco C (1979) Immune phagocytosis in murine malaria. J Exp Med 149:1288–1298
Smith AR, Karr LJ, Lykins JD, Ristic M (1972) Serum soluble antigens of malaria: A review. Exp Parasitol 31:120–125
Taylor DW, Siddiqui WA (1978) Suppression of lymphocyte transformation by plasma from owl monkeys acutely infected with Plasmodium falciparum. Infect Immun 21:147–150
Trager W, Jensen J (1980) Cultivation of erythrocytic and exoerythrocytic stages of Plasmodia. In: Kreier JP (ed) Malaria. Academic Press, New York, pp 271–328
Virgin HW, Unanue ER (1984) Suppression of the immune response to Listeria monocytogenes 1: immune complexes inhibit resistance. J Immunol 133:104–109
Virgin HW, Wittenberg GF, Bancroft GJ, Unanue ER (1985) Suppression of immune response to Listeria monocytogenes: Mechanism(s) of immune complex suppression. Infect Immun 50:343–353
Wells RA, Pavanand K, Zolyomi S, Permpanich B, MacDermott RP (1980) Anti-lymphocytotoxic antibodies in sera of Thai adults infected with Plasmodium falciparum and Plasmodium vivax. Clin Exp Immunol 39:663–667
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Alder, J.D., Brooks-Alder, B. & Kreier, J.P. Plasmodium berghei malaria: effect of acute phase serum on immunity generated in rats by infection and by vaccination. Parasitol Res 74, 116–122 (1987). https://doi.org/10.1007/BF00536022
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DOI: https://doi.org/10.1007/BF00536022