Abstract
Chonemorphine, a steroidal alkaloid isolated from Chonemorpha fragrans Moon (Apocyanaceae) was identified as an antimoebic principle during the course of a screening programme for novel antiparasitic agents from plant sources. At a dosage of 100 mg/kg × 4 chonemorphine led to a 100% cure of experimental hepatic infection in golden hamsters and cleared 90% of the intestinal infection in weanling Wistar rats at 200 mg/kg (x 4) dosages. The discovery of chonemorphine as an antiamoebic agent is an addition to the few known plant amoebicides such as emetine and conessine.
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Chatterjee, D.K., Iyer, N. & Ganguli, B.N. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res 74, 30–33 (1987). https://doi.org/10.1007/BF00534928
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DOI: https://doi.org/10.1007/BF00534928