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Distribution of OMP-, PGP 9.5- and CaBP-like immunoreactive chemoreceptor neurons in the developing human olfactory epithelium

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Abstract

We have examined the distribution of olfactory marker protein (OMP), protein gene product 9.5 (PGP 9.5) and calcium-binding protein D-28k (CaBP) in the olfactory epithelium of mid- to late fetal and newborn humans using immunocytochemistry. Olfactory chemoreceptor neurons (ORNs) in a 24-week-old female fetus, a 31-week-old male fetus and a newborn male were examined. OMP-like immunoreactivity (-LI) and PGP 9.5-LI were distributed throughout ORNs at all ages. CaBP-like immunoreactivity, however, was found only in clustered or isolated fetal ORNs; in the newborn, CaBP-LI was seen only in isolated ORNs sparsely distributed throughout the OE. These findings demonstrate that human ORNs express OMP-LI nearly 4 weeks earlier in development than previously reported. PGP 9.5-LI is coincidentally abundant within these cells, suggesting it may have an important role in mature ORNs. Because the number of ORNs expressing CaBP-LI decreases during perinatal development, CaBP may be important in intracellular calcium regulation during ORN growth and maturation in the developing OE.

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Authors and Affiliations

  1. Department of Otolaryngology and The Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, 80262, Denver, CO, USA

    E. W. Johnson, P. M. Eller & B. W. Jafek

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  1. E. W. Johnson
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  2. P. M. Eller
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  3. B. W. Jafek
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Correspondence to E. W. Johnson.

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Johnson, E.W., Eller, P.M. & Jafek, B.W. Distribution of OMP-, PGP 9.5- and CaBP-like immunoreactive chemoreceptor neurons in the developing human olfactory epithelium. Anat Embryol 191, 311–317 (1995). https://doi.org/10.1007/BF00534683

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