Skip to main content
Log in

Untersuchungen der Aktivitäten des Coeruloplasmins, der SGOT, der SGPT und der Cholinesterase bei manchen Neoplasmaformen

Changes in oxidase activity of ceruloplasmin, SGOT, SGPT and cholinesterase in some forms of malignant tumours

  • Published:
Zeitschrift für Krebsforschung Aims and scope Submit manuscript

Summary

Results are reported of changes in serum GOT, GPT, ceruloplasmin and cholinesterase examined in 195 patients with various malignant tumours. In patients with liver metastases the oxidase activity of ceruloplasmin and the activity of cholinesterase rose, a fact that may be explained by the increased permeability of membranes of liver-cells. The activity of SGOT and SGPT decreased in all examined groups of patients with the exception of those with stomach cancer.

Zusammenfassung

Das Ergebniss von Untersuchungen der Serumenzymaktivität des Coeruloplasmins, der GOT, der GPT sowie der serum-Cholinesterase bei 195 Kranken mit verschiedenen nach Art und Lokalisation malignen Neubildungen wird mitgeteilt. Bei Kranken mit Metastasen in der Leber wird eine hohe Oxydaseaktivität des Coeruloplasmins und der Cholinesterase festgestellt, welche auf eine erhöhte Durchlässigkeit der Leberzellmembranen hinweist. SGOT und SGPT sind bei allen untersuchten Gruppen von Kranken mit Ausnahme der Magenkrebsfälle mit Metastasen in der Leber erniedrigt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  • Abercrombie, M., and E. J. Ambrose: The surface properties of cancer cells: a review. Cancer Res. 22, 525–548 (1962).

    Google Scholar 

  • Berezov, T. T.: A comparative study of transamination reactions of dicarboxylic acids and of their amides in the cancer of the human stomach (Russ.) Biochimia 24, 1079–1084 (1959).

    Google Scholar 

  • Cormack, D. H., G. C. Easty, and E. J. Ambrose: Interaction of enzymes with normal and tumour cells. Nature (Lond.) 190, 1207–1208 (1963).

    Google Scholar 

  • Gubler, C. J., H. Brown, H. Markowitz, G. E. Cartwright, and M. M. Wintrobe: Studies on copper metabolism. XXIII. Portal (Laennec's) cirrhosis of the liver. J. clin. Invest. 36, 1208–1212 (1957).

    Google Scholar 

  • Hořejši, J.: Enzymatische Systeme der Leberzelle und Veränderungen ihrer Aktivität in pathologischen Zuständen. Symposium der klnischen Chemie, Warszawa, 27–28 XI, 1964.

  • Ivanova, E. N.: Spurelementen — Inhalt in manchen menschlichen Neoplasmen und experimentellen Neubildungen. Dissertation, Donezk, 1958.

  • Lerman, M. J.: Reamination of amides in tissues of malignant tumors (Russ.). Vopr. Onkologii 7, No. 10, 40–44 (1961).

    Google Scholar 

  • Markowitz, H., C. J. Gubler, J. P. Machoney, G. E. Cartwright, and M. M. Wintrobe: Studies on copper metabolism. XIV. Copper ceruloplasmin and oxidase activity in of normal human subjects, pregnant women and patients with infection, hepatolenticular degeneration and the nephrotic syndrome. J. clin. Invest. 34, 1498–1503 (1955).

    Google Scholar 

  • Pineda, E. P., H. A. Ravin, and A. M. Rutenberger: Serum ceruloplasmin: Observations in patients with cancer, obstructive jaundice and other diseases. Gastroenterology 43, 266–270 (1962).

    Google Scholar 

  • Piper, D. W., E. M. Griffith, M. L. Macoun, F. L. Broderick, and B. H. Fenton: Relationship of activities of lactic dehydrogenase, beta glucuronidase and glutamic oxalacetic transaminase in gastric carcinoma to that in fundic and pyloric mucosa. Cancer 18, 1055–1058 (1965).

    Google Scholar 

  • Potopalskiy, A. I., E. M. Neyko, W. K. Bondartschuk u. A. M. Fedortschuk: Aktivitätsveränderungen des Ceruloplasmins (Cuprooxydase) bei dem Geschwulstwuchs (Russ.). in “Vopros. exper. Onkologii”, Kiew, S. 169–172, 1965.

  • Ravin, H. A.: An improved colorimetric enzymatic assay of ceruloplasmin. J. Lab. clin. Med. 58, 161–165 (1961).

    Google Scholar 

  • Reitman, S., and S. Frankel: A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Amer. J. clin. Path. 28, 56–63 (1957).

    Google Scholar 

  • Rosenfeld, I., and C. A. Tobias: Distribution of Co60, Cu64 and Zn65 in the cytoplasm and nuclei of tissues. J. biol. Chem. 191, 339–349 (1951).

    Google Scholar 

  • Scheinberg, I. H., and I. Sternlieb: Copper metabolism. Pharmacol. Rev. 12, 355–381 (1960).

    Google Scholar 

  • Sternlieb, I., and I. H. Scheinberg: Ceruloplasmin in health and disease. Ann. N. Y. Acad. Sci. 94, 71–76 (1961).

    Google Scholar 

  • Sullivan, J. F., and K. T. Hart: Serum benzidine oxidase. J. Lab. clin. Med. 55, 260–267 (1960).

    Google Scholar 

  • Sylvén, B., and I. Bois: Protein content and enzymatic assays of interstitial fluid from some normal tissues and transplanted mouse tumors. Cancer Res. 20, 831–836 (1960).

    Google Scholar 

  • Tschilov, K.: Klinische Laboratorie (Bulg.), M. F., Sofia, S. 324–337, 1959.

  • Wu, R.: Leacage of enzymes from ascites tumor cells. Cancer Res. 19, 1217–1222 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bozhkov, B., Popova, N. & Draganov, I. Untersuchungen der Aktivitäten des Coeruloplasmins, der SGOT, der SGPT und der Cholinesterase bei manchen Neoplasmaformen. Z Krebs-forsch 72, 72–76 (1969). https://doi.org/10.1007/BF00524797

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00524797

Navigation