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Acetals of lactams and acid amides. 38. Synthesis of pyrimidine and pyridine derivatives on the basis of the reaction of enamino amides with amide acetals

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Abstract

Derivatives of 1-benzyl-4-pyrimidinones and 1-benzyl-6-pyrimidinones were synthesized by the reaction of β-cyano-3-N-benzylaminocrotonamide and α-cyano-β-aminocrotonic acid N-benzylamine with dimethylformamide diethylacetal. When 1-benzyl-5-cyano-6-(β-dimethylamino)vinyl-1,6-dihydro-4-pyrimidinone is heated in an alkaline medium, it is converted to 3-cyano-4-benzylamino-2-pyridone, from which a pyrido[1,2-a]pyrimidine derivative was synthesized. When 1-benzyl-5-cyano-4-(β-dimethylamino) vinyl-1,6-dihydro-6-pyrimidinone is heated in alkaline solution, it is converted to α-cyano-β-hydroxycrotonic acid N-benzylamide.

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Literature cited

  1. S. I. Kaimanakova, E. F. Kuleshova, N. P. Solov'eva, and V. G. Granik, Khim. Geterotsikl. Soedin., No. 11, 1553 (1982).

    Google Scholar 

  2. V. A. Azimov, V. G. Granik, R. G. Glushkov, and L. N. Yakhontov, Khim. Geterotsikl. Soedin., No. 3, 355 (1978).

    Google Scholar 

  3. V. G. Granik, A. M. Zhidkova, R. A. Dubinskii, Khim. Geterotsikl. Soedin., No. 4, 518 (1982).

    Google Scholar 

  4. V. G. Granik, N. B. Marchenko, T. F. Vlasova, and R. G. Glushkov, Khim. Geterotsikl. Soedin., No. 11, 1509 (1976).

    Google Scholar 

  5. V. G. Granik, E. O. Sochneva, N. P. Solov'eva, E. A. Kuleshova, and O. S. Anisimova, Khim. Geterotsikl. Soedin., No. 8, 1120 (1980).

    Google Scholar 

  6. M. S. Goizman and R. A. Dubinskii, Summaries of Papers Presented at the 4th All-Union Conference on the Analytical Chemistry of Organic Compounds [in Russian], Moscow (1980), p. 224

  7. S. S. Kiselev, M. K. Polievktov, and V. G. Granik, Khim. Geterotsikl. Soedin., No. 9, 1231 (1979).

    Google Scholar 

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow

    V. G. Granik & S. I. Kaimanakova

Authors
  1. V. G. Granik
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  2. S. I. Kaimanakova
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Additional information

See [1] for Communication 37.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 816–820, June, 1983.

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Granik, V.G., Kaimanakova, S.I. Acetals of lactams and acid amides. 38. Synthesis of pyrimidine and pyridine derivatives on the basis of the reaction of enamino amides with amide acetals. Chem Heterocycl Compd 19, 657–661 (1983). https://doi.org/10.1007/BF00523081

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  • DOI: https://doi.org/10.1007/BF00523081

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