Summary
Bovine hypophyseal intermediate lobe tissue and colloid have a particular affinity for adult cells of mesodermal origin. Intermediate lobe materials utilized as an erythropoietic stimulant induces the proliferation of glomerular capillary endothelial cells.
These cells meet the requirements of erythroid precursors for they demonstrate that they belong to a class capable of proliferating, differentiating and undergoing multiple divisions resulting in the formation of colonies of cells belonging to the erythroid series.
The present observations show that intermediate lobe materials simulate erythropoietin(s) and that endothelial cells, when properly stimulated, differentiate along the erythroid cell line.
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Boyd, W.H. Proliferation of glomerular capillary endothelial cells under the influence of hypophyseal intermediate lobe materials. Z. Anat. Entwickl. Gesch. 130, 306–315 (1970). https://doi.org/10.1007/BF00521000
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DOI: https://doi.org/10.1007/BF00521000