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Genetic control of immunoglobulin allotypes in the fowl

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Abstract

Eight immunoglobulin allotypic specificities have been identified in the fowl by isoimmunization. Aa1 and Aa2 are controlled as codominants at the a locus, Ab1 and Ab2 at the b locus, and Ac1, Ac2, Ac3, and Ac4 at the c locus. Column chromatography and ultracentrifugation indicate that the specificities at the a locus are located on molecules corresponding to IgG with sedimentation coefficients 7 S. Immunoelectrophoresis results also indicate that we are dealing with an immunoglobulin G molecule. Further tests are underway to resolve this beyond doubt.

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References

  • Dray, S., and Young, G. O. (1958). Differences in the antigenic components of sera of individual rabbits as shown by induced isoprecipitins. J. Immunol. 81 142.

    Google Scholar 

  • Dray, S., Kelus, A., Dubiski, S., Lennox, E. S., and Oudin, J. (1962). A notation for allotypy. Nature 195 785.

    Google Scholar 

  • Lieberman, R., and Dray, S. (1964). Five allelic genes at the Asa locus which control gamma globulin allotypic specificities in mice. J. Immunol. 93 584.

    Google Scholar 

  • Oudin, J. (1956). The “allotypy” of certain protein antigens of serum. Compt. Rend. Acad. Sci. (Paris) 242 2606.

    Google Scholar 

  • Rapacz, J., Korda, N., and Stone, W. H. (1968). Serum antigens of cattle. I. Immunogenetics of a macroglobulin allotype. Genetics 58 387.

    Google Scholar 

  • Rasmusen, B. A. (1965). Isoantigens of gamma globulin in pigs. Science 148 1742.

    Google Scholar 

  • Skalba, D. (1964). Allotypes of hen serum proteins. Nature 200 894.

    Google Scholar 

  • Warner, N. L., and Herzenberg, L. A. (1967). Immunoglobulin isoantigens (allotypes) in the mouse. IV. Allotypic specificities common to two distinct immunoglobulin classes. J. Immunol. 99 675.

    Google Scholar 

  • Warner, N. L., Herzenberg, L. A., and Goldstein, G. (1966). Immunoglobulin isoantigens (allotypes) in the mouse. II. Allotypic analysis of three γG2-myeloma proteins from (NZB × Balb/c) F1 hybrids and of normal γG2-globulins. J. Exptl. Med. 123 707.

    Google Scholar 

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Author notes

  1. C. S. David

    Present address: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan

Authors and Affiliations

  1. Department of Poultry Science, Iowa State University, Ames, Iowa

    C. S. David & A. W. Nordskog

  2. Department of Veterinary Microbiology, Iowa State University, Ames, Iowa

    M. L. Kaeberle

Authors
  1. C. S. David
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  2. M. L. Kaeberle
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  3. A. W. Nordskog
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Additional information

Journal Paper No. 5405 of the Iowa Agricultural and Home Economics Experiment Station, Ames, Iowa. Project 1039. Supported in part by National Science Foundation Grants GB 318 and GB 4450.

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David, C.S., Kaeberle, M.L. & Nordskog, A.W. Genetic control of immunoglobulin allotypes in the fowl. Biochem Genet 3, 197–206 (1969). https://doi.org/10.1007/BF00520354

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  • DOI: https://doi.org/10.1007/BF00520354

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