Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 306, Issue 1, pp 89–92 | Cite as

Interaction of cations and chelators with the intestinal absorption of tetracycline

  • H. Poiger
  • Ch. Schlatter


The influence of certain compounds on intestinal absorption of tetracycline was tested, using two different in vivo techniques: a) Disappearence of the drug from perfused intestinal segments of the rabbit; b) Measuring urinary excretion in the rat after oral dosage.

Ca2+ and Fe2+ ions both reduced the permeation rate of tetracycline by about 30%. In presence of Ca2+ and salicylate ions, leading to ion-pair formation with the antibiotic, intestinal uptake was significantly increased in comparison to experiments where only calcium was present. A more pronounced increase was observed with EDTA.

Phosphate ions had different effects on the uptake of the antibiotic in both experimental techniques. Possible mechanisms are discussed.

Key words

Tetracycline absorption Salicylic acid EDTA Phosphate Ions 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • H. Poiger
    • 1
  • Ch. Schlatter
    • 1
  1. 1.Institute of ToxicologySwiss Federal Institute of Technology and University of ZürichSchwerzenbach-ZürichSwitzerland

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