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Ca2+ Ions Regulate Activity of Na+,Cl–(HCO −3 )-ATPase in the Mucosa of Rabbit Small Intestine

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of bivalent metal ions on activity of Na+,Cl–(HCO3 –)-ATPase was studied. In contrast to Ba2+, Co2+, Zn2+, and Mn2+ ions, Ca2+ and Mg2+ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+,Cl–(HCO3 –)-ATPase. A possible mechanism of regulation of enzyme activity by Ca2+ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl– ions was proposed.

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Authors and Affiliations

  1. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia

    V. A. Yurkiv, V. I. Melikhov & V. S. Shubin

Authors
  1. V. A. Yurkiv
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  2. V. I. Melikhov
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  3. V. S. Shubin
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Correspondence to V. S. Shubin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 308-311, September, 2014

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Yurkiv, V.A., Melikhov, V.I. & Shubin, V.S. Ca2+ Ions Regulate Activity of Na+,Cl–(HCO −3 )-ATPase in the Mucosa of Rabbit Small Intestine. Bull Exp Biol Med 158, 326–328 (2015). https://doi.org/10.1007/s10517-015-2753-8

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  • DOI: https://doi.org/10.1007/s10517-015-2753-8

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