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Reduction of 2,3,4-substituted quinolines with sodium borohydride

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

1,2-Dihydroquinolines were obtained by the reduction of 3-substituted 2-methyl-4-phenylquinolines with sodium borohydride in aliphatic carboxylic acids; N-alkyl derivatives are also formed. The corresponding 1,4-dihydroquinoline was obtained in the reaction of 2-methyl-3-nitroquinolinium perchlorate with sodium borohydride.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Latvian Academy of Sciences, 226006, Riga

    B. A. Vigante, Ya. Ya. Ozols & G. Ya. Dubur

Authors
  1. B. A. Vigante
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  2. Ya. Ya. Ozols
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  3. G. Ya. Dubur
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1680–1686, December, 1991.

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Vigante, B.A., Ozols, Y.Y. & Dubur, G.Y. Reduction of 2,3,4-substituted quinolines with sodium borohydride. Chem Heterocycl Compd 27, 1352–1357 (1991). https://doi.org/10.1007/BF00515581

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  • DOI: https://doi.org/10.1007/BF00515581

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