Abstract
The reaction of esters of alkyl-substituted (E)-5-amino-4-hydroxy-2,3,epoxyvaleric acids with some hydrohalic acids gave the corresponding 2-halo-4-amino-methyl-2-buten-4-olides, the hydrochlorides of which have diuretic activity.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1471–1474, November, 1985.
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Tyvorskii, V.I., Tishchenko, I.G., Kukharev, A.S. et al. Synthesis of alkyl-substituted 2-halo-4-aminomethyl-2-buten-4-olides. Chem Heterocycl Compd 21, 1210–1213 (1985). https://doi.org/10.1007/BF00515212
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DOI: https://doi.org/10.1007/BF00515212