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Synthesis of 5-n-alkyl-2-(trans-4-n-alkylcyclohexyl)pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The cyclization of trans-1-acrylyl-4-n-alkylcyclohexanes with trans-1-N-piperidino-1-alkenes was used to synthesize 3-n-alkyl-6-(trans-4-n-alkyl-cyclohexyl)-3,4-dihydro-2-N-piperidino-2H-pyrans, which were converted under the influence of hydroxylamine to 5-n-alkyl-2-(trans-4-n-alkylcyclohexyl)-pyridines. Problems in the stereochemistry of the cyclohexane derivatives in the investigated scheme of synthesis were examined.

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Authors and Affiliations

  1. Scientific-Research Institute of Organic Intermediates and Dyes, 103787, Moscow

    A. I. Pavlyuchenko, G. V. Purvanetskas, V. K. Daukshas, N. I. Smirnova, N. I. Korotkova & E. I. Kovshev

Authors
  1. A. I. Pavlyuchenko
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  2. G. V. Purvanetskas
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  3. V. K. Daukshas
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  4. N. I. Smirnova
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  5. N. I. Korotkova
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  6. E. I. Kovshev
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 643–647, May, 1984.

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Pavlyuchenko, A.I., Purvanetskas, G.V., Daukshas, V.K. et al. Synthesis of 5-n-alkyl-2-(trans-4-n-alkylcyclohexyl)pyridines. Chem Heterocycl Compd 20, 515–518 (1984). https://doi.org/10.1007/BF00514304

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  • DOI: https://doi.org/10.1007/BF00514304

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