Summary
The inhibitory action of harmaline on l-phenylalanine uptake by guinea-pig intestinal rings is fully reversible provided only low concentrations of the inhibitor are used; if the concentration is raised to a sufficient extent to enable the drug to interfere with sodium pumping or cellular metabolic reactions, as witnessed by its effect on tissue oxygen consumption, then the inhibition of l-phenylalanine uptake is only reversible if short contact times are employed.
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Buclon, M., Sepúlveda, F.V. & Robinson, J.W.L. The reversibility of the inhibition of intestinal amino-acid transport by harmaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 57–59 (1977). https://doi.org/10.1007/BF00510987
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DOI: https://doi.org/10.1007/BF00510987