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Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronchial asthma of the guinea pig

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Summary

  1. 1.

    Sodium nitroprusside (NP) is a potent relaxant of the guinea pig's tracheal smooth muscle contracted by carbachol or histamine.

  2. 2.

    At high doses, aerosols of NP delay the occurrence of symptoms of bronchial asthma in guinea pigs subjected to a histamine aerosol. However, the β-adrenergic bronchodilator isoprenaline is at least 2,600 times more potent as an anti-asthmatic than NP on a molar basis.

  3. 3.

    NP and isoprenaline both reduce the blood pressure in rats when given either as infusion or as aerosol. The aerosol/infusion dosage ratio for comparable reductions of blood pressure were 1 for isoprenaline, and 10 for NP. After cessation of the application of the NP aerosol, the blood pressure rose more than twice as fast (t 1/2 of blood pressure recovery) than after cessation of the application of the isoprenaline aerosol.

  4. 4.

    The poor antiasthmatic effect of NP aerosols may result from low permeability of the bronchial epithelium to the NP anion, from partial destruction in the airways or during tissue permeation, and from short half life of NP in the circulating blood.

  5. 5.

    Because of its inferiority to known bronchodilators, aerosols of NP cannot be recommended for the treatment of acute bronchial asthma.

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References

  • Casinelli, C. M.: La action hipotensora del nitroprusiato aplicationes therapeuticas. Anales de la Facultad de Medicina Universidad nacional mayor de San Marcos de Lima 39, 1330–1331 (1956)

    Google Scholar 

  • Castillo, J. C., de Beer, E. J.: The tracheal chain. I. A preparation for the study of antispasmodics with particular reference to bronchodilator drugs. J. Pharmacol. Exp. Ther. 90, 104–109 (1947)

    Google Scholar 

  • Dautrebande, L., Philipot, E., Nogarode, F., Charlier, R.: Aerosols médicamenteux. I. Pénétration dans l'organisme et action à distance de substances médicamenteuses introduites par voie transpulmonaire. Arch. Int. Pharmacodyn. 66, 138–167 (1941)

    Google Scholar 

  • David, H. A., Hartley, H. O., Pearson, E. S.: The distribution of the ratio, in a single normal sample, of range to standard deviation. Biometrika 41, 482–493 (1954)

    Google Scholar 

  • Halpern, B. N.: Les antihistaminiques de synthèse. Essais de chimithérapy des états allergiques. Arch. Int. Pharmacodyn. 68, 339–408 (1942)

    Google Scholar 

  • Herxheimer, H.: Repeatable microshocks of constant strength in guinea-pig anaphylaxis. J. Physiol. (Lond.) 117, 251–255 (1952)

    Google Scholar 

  • Hill, H. E.: A contribution to the toxicology of sodium nitroprusside. 1. The decomposition and determination of sodium nitroprusside. Austral. Chem. Inst. J. Proc. 9, 89–93 (1942)

    Google Scholar 

  • Höbel, M., Maroske, D., Eichler, O.: Eine einfache Methode zur Bestimmung des Atemminutenvolumens von Ratten und Meerschweinchen. Arch. Int. Pharmacodyn. 194, 371–374 (1971)

    Google Scholar 

  • Kreye, V. A. W., Baron, G. D., Lüth, J. B., Schmidt-Gayk, H.: Mode of action of sodium nitroprusside on vacular smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 381–402 (1975)

    Google Scholar 

  • Kreye, V. A. W., Reske, S. N., Schultz, K. D.: Vasodilatatorisch wirkende Antihypertensiva: Modellsubstanz Natrium-Nitroprussid. Verh. Dtsch. Ges. Kreislaufforsch. 43, 87–96 (1977)

    Google Scholar 

  • Palmer, F., Kingsbury, St. S.: Particle size in nebulized aerosols. Am. J. Pharmacy 124, 112–124 (1952)

    Google Scholar 

  • Preuner, R.: Allergiestudien. I. Die Wirkung der Witterung auf das experimentelle Asthma bronchiale. Z. Hyg. 121, 559–568 (1939)

    Google Scholar 

  • Smith, R. P., Kruszina, H.: Nitroprusside produces cyanide poisoning via a reaction with hemoglobin. J. Pharmacol. Exp. Ther. 191, 557–563 (1974)

    Google Scholar 

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Authors and Affiliations

  1. II Physiologisches Institut and Anatomisches Institut III, Universität Heidelberg, Im Neuenheimer Feld 326, D-6900, Heidelberg, Federal Republic of Germany

    Volker A. W. Kreye & Erich Marquard

Authors
  1. Volker A. W. Kreye
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  2. Erich Marquard
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Additional information

This work was supported by the German Research Foundation (DFG) within SFB 90 “Cardiovascular System”. The experiments were performed at the Pharmacological Institute, University of Heidelberg

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Kreye, V.A.W., Marquard, E. Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronchial asthma of the guinea pig. Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 203–207 (1979). https://doi.org/10.1007/BF00507104

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  • DOI: https://doi.org/10.1007/BF00507104

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