Summary
The intraperitoneal administration of d-amphetamine (0.2–2.5 mg/kg) decreases dihydroxyphenylacetic acid (DOPAC) content not only in the caudate nucleus but also in the substantia nigra. This effect persists both in the substantia nigra and in the caudate nucleus after loss of dopamine-sensitive adenylate cyclase and presumably of dopamine receptors, induced by intrastriatal injection of kainic acid. These results indicate that the effect of amphetamine on DOPAC levels in the nigra is not mediated through a strionigral feedback loop.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aghajanian, G. K., Bunney, B. S.: Central dopaminergic neurons: neurophysiological identification and responses to drugs. In: Frontiers in Catecholamine Research (Usdin, E., Snyder, S., eds.), pp. 641–648. Oxford: Pergamon Press 1973
Argiolas, A., Fadda, F., Stefanini, E., Gessa, G. L.: A simple radioenzymatic method for determination of picogram amounts of 3,4-dihydroxyphenylacetic acid (DOPAC) in the rat brain. J. Neurochem. 29, 599–601 (1977)
Besson, M. J., Cheramy, A., Feltz, P., Glowinski, J.: Dopamine: spontaneous and drug-induced release from caudate nucleus in the cat. Brain Res. 32, 407–424 (1971)
Bunney, B. S., Aghajanian, G. K.: Electrophysiological effects of amphetamine on dopaminergic neurones. In: Frontiers in Catecholamine Research (Usdin, E., Snyder, S., eds.), pp. 957–962. Oxford: Pergamon Press 1973
Bunney, B. S., Aghajanian, G. K.: d-amphetamine-induced inhibition of central dopaminergic neurones: mediation by striatonigral feedback pathway. Science 192, 391–393 (1976)
Carlsson, A., Lindqvist, M.: Effect of chlorpromazine of haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol. Toxicol. 20, 140–144 (1963)
Chiueh, C. C., Moore, K. E.: Blockade by reserpine of methylphenidate-induced release of brain dopamine. J. Pharmacol. Exp. Ther. 193, 559–563 (1975)
Corsini, G. U., Del Zompo, M., Manconi, S., Piccardi, M. P., Onali, P. L., Mangoni, A., Gessa, G. L.: Evidence for dopamine receptors in the human brain mediating sedation and sleep. Life Sci. 20, 1613–1618 (1977)
Coyle, J. T., Schwarcz, R.: Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 263, 244–246 (1976)
Di Chiara, G., Porceddu, M. L., Vargiu, L., Argiolas, A., Gessa, G. L.: Evidence for dopamine receptors mediating sedation in the mouse brain. Nature 264, 564–567 (1976)
Di Chiara, G., Olianas, M., Del Fiacco, M., Spano, P. F., Tagliamonte, A.: Intranigral kainic acid is evidence that nigral nondopaminergic neurones control posture. Nature 268, 743–745 (1977a)
Di Chiara, G., Porceddu, M. L., Spano, P. F., Gessa, G. L.: Haloperidol increases and apomorphine decreases striatal dopamine metabolism after destruction of striatal dopamine-sensitive adenylate cyclase by kainic acid. Brain Res. 130, 374–382 (1977b)
Ferris, R. M., Tang, F. L. M., Maxwell, R. A.: A comparison of the capacities of isomers of amphetamine, deoxypipradol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparation of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta. J. Pharmacol. Exp. Ther. 181, 407–416 (1972)
Gale, K., Guidotti, A., Costa, E.: Dopamine-sensitive adenylate cyclase: location in substantia nigra. Science 195, 503–505 (1977)
Groves, P. M., Wilson, C. J., Young, S. J., Rebec, G. V.: Self-inhibition by dopaminergic neurons. Science 190, 522–529 (1975)
Groves, P. M., Young, S. J., Wilson, C. J.: Self-inhibition by dopaminergic neurons: distruption by (±)-methyl-p-tyrosine pretreatment or anterior diencephalic lesions. Neuropharmacology 15, 755–762 (1976)
Holmes, J. C., Rutledge, C. O.: Effects of the d- and l-isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine and 5-hydroxytryptamine in several regions of the rat brain. Biochem. Pharmacol. 25, 447–451 (1976)
Kehr, W., Carlsson, A., Lindqvist, M., Magnusson, T., Atack, C.: Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity. J. Pharmac. Pharmacol. 24, 744–747 (1974)
Korf, J., Zieleman, M., Westerink, B. H. C.: Dopamine release in substantia nigra? Nature 260, 257–258 (1976)
Nieoullon, A., Cheramy, A., Glowinski, J.: Release of dopamine “in vitro” from cat substantia nigra. Nature 266, 375–377 (1977)
Paden, C., Wilson, C. J., Groves, P. M.: Amphetamine-induced release of dopamine from the substantia nigra “in vitro”. Life Sci. 19, 1499–1506 (1976)
Palkovits, M., Brownstein, M., Saveedra, J. M., Axelrod, J.: Norepinephrine and dopamine content of hypothalamic nuclei of the rat. Brain Res 77, 137–149 (1974)
Renshaw, D. C.: In: The hyperactive child, pp. 36–40. Chicago: Nelson-Hall 1974
Roffler-Tarlov, S., Sharman, D. F., Tegerdine, P.: 3,4-Dihydroxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid in the mouse striatum: a reflection of intra- and extra-neuronal metabolism of dopamine? Br. J. Pharmacol. 42, 343–351 (1971)
Schwarcz, R., Coyle, J. T.: Striatal lesions with kainic acid: neurochemical characteristics. Brain Res. 127, 235–249 (1977)
Spano, P. F., Trabucchi, M., Di Chiara, G.: Localization of nigral dopamine-sensitive adenylate cyclase on neurons originating from the corpus striatum. Science 196, 1343–1345 (1977)
Spano, P. F., Di Chiara, G., Tonon, G., Trabucchi, M.: A dopamine-stimulated adenylate cyclase in rat substantia nigra. J. Neurochem. 27, 1565–1568 (1976)
Tecce, J. J., Cole, J. O.: Amphetamine effects in man: paradoxical drowsiness and lowered electrical brain activity (CNV). Science 185, 451–453 (1974)
Weiss, B., Laties, U. G.: Enhancement of human performance by caffeine and the amphetamines. Pharmacol. Rev. 14, 1–36 (1962)
Westerink, B. H. C., Korf, J.: Determination of nanogram amounts of homovanillic acid in the nervous central system with a rapid semiautomated fluorometric method. Biochem. Med. 12, 106–115 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Argiolas, A., Fadda, F., Stefanini, E. et al. Evidence for a direct action of amphetamine on dopamine metabolism in the rat substantia Nigra in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 301, 171–174 (1978). https://doi.org/10.1007/BF00507033
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00507033