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Side-effects of local anesthetics on the corneal epithelium of the rabbit eye

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Summary

The toxic side-effects of 0.4% Novesine and Chibro-Kerakain were investigated by scanning- and transmission electron microscopy in 15 rabbit corneae each in intervals of 3, 6, 10, 15 and 60 mins. The lesions following Kerakain were larger and occurred earlier. After 60 mins, the specimens after Novesine application showed an almost complete repair process, whereas after Kerakain the epithelial surface appeared to be functionally impaired.

Zusammenfassung

Raster- und transmissionselektronenmikroskopisch werden 15 Kaninchenhornhäute nach Novesin 0,4%und 15 nach Chibro-Keracain in Abständen von 3, 6, 10, 15 und 60 min auf toxische Nebenwirkungen untersucht. Die Läsionen nach Keracain waren ausgeprägter und traten rascher ein. 60 min nach Applikation sind die Reparationsvorgänge bei Novesin weitgehendst abgeschlossen. Die Präparate nach Keracain zeigen zu diesem Zeitpunkt ein in seiner Funktion noch beeinträchtigtes Oberflächenepithel.

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Authors and Affiliations

  1. Ophthalmic Clinic of the Klinikum Steglitz, Freie Universität Berlin, Deutschland

    J. P. Harnisch, F. Hoffmann & L. Dumitrescu

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  1. J. P. Harnisch
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  2. F. Hoffmann
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  3. L. Dumitrescu
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Harnisch, J.P., Hoffmann, F. & Dumitrescu, L. Side-effects of local anesthetics on the corneal epithelium of the rabbit eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 197, 71–81 (1975). https://doi.org/10.1007/BF00506644

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  • DOI: https://doi.org/10.1007/BF00506644

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