Summary
Field stimulation produced in isolated guinea-pig left atria a positive inotropic response, which was highly sensitive to the inhibitory actions of lidocaine, tetrodotoxin, and of pindolol. The field-stimulus effect was enhanced by angiotensin and by bradykinin, but not by substance P. Only bradykinin exerted also a direct positive inotropic effect (in the absence of field stimulation). It is concluded that the intramural adrenergic neurons of the guinea-pig atrium have receptors for both angiotensin and bradykinin, but not for substance P.
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Iven, H., Pursche, R. & Zetler, G. Field-stimulus response of guinea-pig atria as influenced by the peptides angiotensin, bradykinin, and substance P. Naunyn-Schmiedeberg's Arch. Pharmacol. 312, 63–68 (1980). https://doi.org/10.1007/BF00502576
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DOI: https://doi.org/10.1007/BF00502576