Summary
By a new technique it is possible to obtain nasal mucus in native form. By immunoencymatic methods simultaneously the IgE levels in nasal mucus and in serum were determined in 100 patients with allergic disorders in the upper respiratory tract. All patients with positive skin reaction and positive provocation test showed an IgE level 10–70 times above normal. In contrast 30% false negative results were obtained with IgE determination in serum. The IgE level is only 2–10 times over normal in serum with patients with positive skin test. The IgE concentration in nasal mucus can be related to the protein content determined by UV-spectroscopy. With this technique the reliability of accuracy of the IgE level in nasal mucus is increased.
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Eichner H (1979) Eine neue Methode zur Gewinnung von Nasensekret und erste Untersuchungen zur Eiwei\zusammensetzung des Nasensekretes mittels Diskelektrophorese. Laryngol Rhinol Otol (Stuttg) 58: 269
Hobday JD (1971) A comparison of the immunoglobulins IgA, IgG and IgE in nasal secretions from normal and asthmatic children. Clin Exp Immunol 9: 577
Huggins KG, Brostoff J (1975) Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests. Lancet 1: 148
Ishizaka K, Newcomb RW (1970) Presence of IgE in nasal washings and sputum from asthmatic patients. J Allergy Clin Immunol 46: 197
Merrett TG (1976) Measurement of specific IgE antibodies in nasal secretion — evidence for local production. Clin Allergy 6: 69
Mygind N (1975) Quantitative determination of immunoglobulins in nasal secretion. Int Arch Allergy Appl Immunol 49: 99
Mygind N (1978) Nasal allergy. Blackwell, Oxford
Waldman RH (1973) IgE levels in external secretions. Int Arch Allergy Appl Immunol 242
Yunginger JW, Gleich GJ (1973) Seasonal changes in serum and nasal IgE concentrations. J Allergy Clin Immunol 51: 174
Zühlke D, Handrock M (1976) Immunologische Untersuchungen des Nasensekrets bei allergischen Rhinitiden und bei vasomotorischen Rhinopathien. Krankenhausarzt 49: 45
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Behbehani, A., Hochstrasser, K., Eichner, H. et al. Zur diagnostischen Bedeutung der IgE-Konzentration im Nasensekret und im Serum bei allergischen Erkrankungen der oberen Luftwege. Arch Otorhinolaryngol 231, 792–795 (1981). https://doi.org/10.1007/BF00501750
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DOI: https://doi.org/10.1007/BF00501750