Summary
The uptake and release of 14C-dopamine and the effect of morphine on these processes were studied in slices of rat striata. The uptake of the labelled dopamine was completed after 30 min. Low temperature, DNP and ouabain inhibited the accumulation of dopamine. Morphine (1.2 and 3.5×10−5 M) did not affect the uptake of labelled dopamine, but it slowed the K+-induced release of 14C-dopamine. Naloxone significantly inhibited this effect of morphine. Our results demonstrate a direct and specific action of morphine on dopaminergic neurones of rat brain.
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Celsen, B., Kuschinsky, K. Effects of morphine on kinetics of 14C-dopamine in rat striatal slices. Naunyn-Schmiedeberg's Arch. Pharmacol. 284, 159–165 (1974). https://doi.org/10.1007/BF00501120
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DOI: https://doi.org/10.1007/BF00501120