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The mechanism of the anti-inflammatory effect of turpentine in the rat

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Summary

  1. 1.

    The influence of counter irritation by turpentine on carrageenan-oedema, leucocyte count, plasma kininogen stores and composition of sponge-induced exudates has been investigated in the rat.

  2. 2.

    Counter irritation reduced the carrageenan-oedema in normal as well as in adrenalectomized rats. It induced leucopenia with lymphopenia but did not modify the plasma kininogen stores.

  3. 3.

    In turpentine-pretreated rats, the exudates induced by sponge implantation 18 h previously had a lower content in leucocytes. Their levels in β-glucuronidase and β-galactosidase were slightly reduced, their content in PGE2 was not modified and their level in malonaldehyde was increased.

    The exudates induced by sponge implantation 4 h previously had a lower content in leucocytes and PGE2 while their level in kinins was not modified.

  4. 4.

    The mechanism of the anti-inflammatory effect of counter irritation by turpentine is discussed. We suggest that the main factor involved is a decrease in leucocyte accumulation into the exudates.

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Authors and Affiliations

  1. Institut Léon Fredericq, Physiologie humaine, normale et pathologique, Université de Liège, 17 Place Delcour, B-4020, Liège, Belgique

    J. Damas & E. Deflandre

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  1. J. Damas
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  2. E. Deflandre
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Damas, J., Deflandre, E. The mechanism of the anti-inflammatory effect of turpentine in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 327, 143–147 (1984). https://doi.org/10.1007/BF00500909

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  • DOI: https://doi.org/10.1007/BF00500909

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