Summary
Dextro-and levorotatory isomers of 1-(1-phenylcyclohexyl)-3-methylpiperidine (PCMP) were synthesized. Both isomers inhibited spontaneous cerebellar Purkinje neuron firing when applied locally by pressure ejection. This effect was dose-dependent, with the (+)-isomer about 5–7 times more potent than the (−)-isomer. Both isomers also depressed rotarod performance in mice. Again, the (+)-isomer was about 5 times more potent than the (−)-isomer. Both rotarod performance and Purkinje cell discharge were depressed maximally 10–15 min after i.p. injection of drug. Our results suggest a correlation between behavioral performance and central neuron electrophysiological activity and suggest that the central actions of PCP or its derivatives are probably mediated at one locus, by a stereospecific mechanism.
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Marwaha, J., Palmer, M., Hoffer, B. et al. Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine. Naunyn-Schmiedeberg's Arch. Pharmacol. 315, 203–209 (1981). https://doi.org/10.1007/BF00499836
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DOI: https://doi.org/10.1007/BF00499836