Summary
The role of neostriatal dopamine in the control of motor function was investigated by assessment of the asymmetric motor behaviour resulting from the unilateral intracaudate administration of pharmacological and neurochemical substances. The unilateral intracaudate administration of 100 μg dopamine to saline pretreated rats induced a mild contralateral asymmetry but lower doses of dopamine were ineffective. Dopamine was similarly active by intrapallidal injection but no asymmetries were observed following injections into the thalamus, nucleus lateralis septi, cerebral cortex or area preoptica. Pretreatment with haloperidol, nialamide or a combination of these two agents increased the sensitivity of caudate tissue to the dopamine effect. This enhancement was shown to be specific for the neuroleptic agents (haloperidol, clothiapine and oxypertine were effective whilst aceperone and phenoxybenzamine were relatively ineffective) and the contralateral behaviour specific for dopamine (noradrenaline, RS 86, procaine, chlorpromazine, trifluphenazine, amitriptyline and protripytline were ineffective) although a contralateral asymmetry was observed following unilateral intracaudate atropine or 5-hydroxytryptamine but these could be differentiated from the dopamine effect. The action of dopamine was mimicked by dopamine agonists and abolished by ablation of the substantia nigra.
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Andén, N.-E.: Effects of amphetamine and some other drugs on central catecholamine mechanisms. In: Amphetamines and related compounds, E. Costa and S. Garattini, Eds., pp. 447–462. New York: Raven Press 1970
Andén, N.-E., Dahlström, A., Fuxe, K., Larsson, K.: Functional role of the nigro neostriatal dopamine neurons. Acta pharmacol. (Kbh.) 24, 263–274 (1966)
Arbuthnott, G. W., Crow, T. J.: Relation of contraversive turning to unilateral release of dopamine from the nigrostriatal pathway in rats. Exp. Neurol. 30, 484–491 (1971)
Bartholini, G., Pletscher, A.: Drugs affecting monoamines in the basal ganglia. In: Advances in biochemical psychopharmacology, E. Costa, L. L. Iversen, and R. Paoletti, Eds., vol. 6, pp. 135–148. Amsterdam: North Holland Publ. Comp. 1972
Bondareff, W., Routtenberg, A., Narotzky, R., McLone, D. G.: Intrastriatal spreading of biogenic amines. Exp. Neurol. 28, 213–229 (1970)
Broch, O. J., Marsden, C. A.: Regional distribution of monoamines in the corpus striatum of the rat. Brain Res. 38, 425–428 (1972)
Cools, A. R.: Intracaudate administration of dopamine in cats. In: The caudate nucleus and neurochemical control of behaviour, pp. 49–93. The Netherlands: Drukkerij Brakkenstein 1973
Corrodi, H., Fuxe, K., Ungerstedt, U.: Evidence for a new type of dopamine receptor stimulating agent. J. Pharm. Pharmacol. 23, 989–991 (1971)
Costall, B., Naylor, R. J., Olley, J. E.: Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain. Neuropharmacol. 11, 645–663 (1972)
Costall, B., Naylor, R. J.: The role of telencephalic dopaminergic systems in the mediation of apomorphine stereotyped behaviour. Europ. J. Pharmacol. 24, 8–24 (1973a)
Costall, B., Naylor, R. J.: The site and mode of action of ET495 for the mediation of stereotyped behaviour in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 117–133 (1973b)
De Groot, J.: The rat forebrain in stereotaxic coordinates. Verh. K. Ned. Akad. Wet. 52, 11–40 (1959)
Dill, R. E., Nickey, W. M., Little, M. D.: Dyskinesias in rats following chemical stimulation of the neostriatum. Tex. Rep. Biol. Med. 26, 101–106 (1968)
Fog, R., Pakkenberg, H.: Behavioural effects of dopamine and p-hydroxyamphetamine injected into corpus striatum of rats. Exp. Neurol. 31, 75–86 (1971)
Greenwood, D. T., Blackburn, T. P.: Effects of fenfluramine and β-bromomethylamphetamine on central dopamine containing neurones in the rat. Presented at the Fifth International Congress of Pharmacology, San Francisco, U.S.A. Abst. 527 (1972)
Hornykiewicz, O.: Dopamine in the basal ganglia. Brit. med. Bull. 29, 172–178 (1973)
Hull, C. D., Buchwald, N. A., Ling, G.: Effects of direct cholinergic stimulation of forebrain structures. Brain Res. 6, 22–35 (1967)
Keller, H. H., Bartholini, G., Pletscher, A.: Drug induced changes of striatal cholinergic and dopaminergic functions in rats with spreading depression. J. Pharm. Pharmacol. 25, 433–436 (1973)
Lotti, V. J.: Action of various centrally acting agents in mice with unilateral caudate brain lesions. Life Sci. 10, 781–789 (1971)
Menon, M. K., Clark, W. G., Aures, D.: The central stimulant and potential antiparkinson effects of 2(p-nitrobenzylthio)-imidazoline (3 H) HCl. Europ. J. Pharmacol. 19, 43–51 (1972)
Naylor, R. J., Olley, J. E.: Modification of the behavioural changes induced by amphetamine in the rat by lesions in the caudate nucleus, caudate-putamen and and globus pallidus. Neuropharmacol. 11, 91–99 (1972)
Ungerstedt, U.: Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta physiol. scand., Suppl. 367, 49–68 (1971a)
Ungerstedt, U.: Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system. Acta physiol. scand., Suppl. 367, 69–93 (1971b)
Ungerstedt, U., Arbuthnott, G. W.: Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. 24, 485–493 (1970)
Ungerstedt, U., Butcher, L. L., Butcher, S. G., Andén, N.-E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 14, 461–471 (1969)
Von Voigtlander, P. F., Moore, K. E.: Turning behaviour of mice with unilateral 6-hydroxydopamine lesions in the striatum: Effects of apomorphine, l-dopa, amantadine, amphetamine and other psychomotor stimulants. Neuropharmacol. 12, 451–462 (1973)
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Costall, B., Naylor, R.J. Specific asymmetric behaviour induced by the direct chemical stimulation of neostriatal dopaminergic mechanisms. Naunyn-Schmiedeberg's Arch. Pharmacol. 285, 83–98 (1974). https://doi.org/10.1007/BF00499529
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DOI: https://doi.org/10.1007/BF00499529