Summary
Amylase secretion “in vitro” was used as an indication of the degeneration activity of sympathetically denervated parotid glands. Seventeen and a half hours after sympathetic denervation, slices of parotid gland released amylase into the incubation medium at a rate higher than that observed for non-denervated glands. The time course of amylase release from denervated glands followed a bellshaped pattern similar to that observed in other denervated structures. Lowering extracellular Ca2+ to 0.25 mmol/l diminished significantly the release of amylase. Low Ca2+ however, did not decrease the amylase release in response to added noradrenaline.
These results indicate that Ca2+ is required for the release of noradrenaline from degenerating nerve endings.
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Baldo, D.d., Peusner, I.C.W. & Stefano, F.J.E. Ca2+ dependence of the release of noradrenaline during nerve degeneration in the parotid gland. Naunyn-Schmiedeberg's Arch. Pharmacol. 328, 41–43 (1984). https://doi.org/10.1007/BF00496104
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DOI: https://doi.org/10.1007/BF00496104