Summary
Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin-and cathepsin D-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin D is suggested to be involved in the regulation of the granular renin stores available for secretion.
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These studies were supported by the German Research Foundation within the SFB 90 “Cardiovasculäres System”
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Taugner, R., Yokota, S., Bührle, C.P. et al. Cathepsin D coexists with renin in the secretory granules of juxtaglomerular epithelioid cells. Histochemistry 84, 19–22 (1986). https://doi.org/10.1007/BF00493415
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DOI: https://doi.org/10.1007/BF00493415