Abstract
N-Pyrimidylcarboxylic acids and their esters, which can be cyclized to tetrahydromidazo-[1,2-a]pyrimidine-2,5-diones, are formed from 2-aminopyrimidine and its C-substituted derivatives by reaction with α-halo acids and their esters under mild conditions. Alkylation proceeds at the N1 and N3 atoms of the pyrimidine ring during the action of unsymmetrical 2-aminopyrimidines with α-halo acids.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1140–1142, August, 1974.
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Mandrichenko, B.E., Mazur, I.A. & Kochergin, P.M. Reaction of 2-aminopyrimidines with αhalocarboxylic acids and their esters. Chem Heterocycl Compd 10, 992–994 (1974). https://doi.org/10.1007/BF00487128
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DOI: https://doi.org/10.1007/BF00487128