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Investigation of 2,3-polymethylenequinolines

XVIII. Kinetics of the reaction of 4-chloro-2,3-polymethylene-quinolines with sodium methoxide

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The rate of the reaction of 4-chloro-6-R-2,3-polymethylenequinolines with sodium methoxide decreases as the number of methylene groups increases; this is explained by the inductive and steric effects of the polymethylene chain. The rate constants of the reaction are in conformity with the Arrhenius equation and are found to exist in a correlation relationship with the σcat substituent constants for quinoline.

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Authors and Affiliations

  1. Perm Pharmaceutical Institute, USSR

    M. E. Konshin, D. I. Uvarov & é. S. Abramochkin

Authors
  1. M. E. Konshin
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  2. D. I. Uvarov
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  3. é. S. Abramochkin
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Additional information

For Communication XVII see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1106–1109, August, 1974.

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Konshin, M.E., Uvarov, D.I. & Abramochkin, é.S. Investigation of 2,3-polymethylenequinolines. Chem Heterocycl Compd 10, 961–964 (1974). https://doi.org/10.1007/BF00487120

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  • DOI: https://doi.org/10.1007/BF00487120

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