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An individual with “Miyada”-like hemoglobin indistinguishable from hemoglobin A2

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Abstract

The hemoglobin of a 24-year-old man of Italian descent who has the phenotypic characteristics of thalassemia intermedia contains about 12% hemoglobin F, 73% hemoglobin A, and 15% hemoglobin A2. Chemical analysis definitely identifies the last as hemoglobin A2. So elevated a percentage of hemoglobin A2 has not been reported before. In addition, the amount of hemoglobin A is unusually large for an individual with presumed homozygosity for β-thalassemia. Although the evidence is indirect, it is suggested that he is heterozygous for two conditions: β-thalassemia and a “Miyada” type of gene that produces a hemoglobin indistinguishable from hemoglobin A2.

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Authors and Affiliations

  1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California

    W. A. Schroeder, J. Roger Shelton & G. Apell

  2. Laboratory of Protein Chemistry, Department of Cell and Molecular Biology, Medical College of Georgia, and Veterans Administration Hospital, Augusta, Georgia

    T. H. J. Huisman

  3. Childrens Hospital of Los Angeles, Los Angeles, California

    Carol Hyman

  4. Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California

    Carol Hyman

Authors
  1. W. A. Schroeder
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  2. T. H. J. Huisman
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  3. Carol Hyman
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  4. J. Roger Shelton
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  5. G. Apell
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Additional information

The work was supported in part by grants HL-02558 and HL-05168 and Training Grant HD-00048 from the National Institutes of Health, U.S. Public Health Service, as well as funds from the Southern California Chapter of the Cooley's Anemia Blood and Research Foundation.

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Schroeder, W.A., Huisman, T.H.J., Hyman, C. et al. An individual with “Miyada”-like hemoglobin indistinguishable from hemoglobin A2 . Biochem Genet 10, 135–147 (1973). https://doi.org/10.1007/BF00485761

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  • DOI: https://doi.org/10.1007/BF00485761

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