Abstract
Three separate somatic cell fusions were made between Chinese hamster lines and human lymphocytes containing (1) a 3/4 translocation, (2) an X/9 translocation, and (3) a 17/9 translocation. Eleven independently derived hybrids showed that only human chromosome 22 was consistently present when human ACON m was expressed and absent when human ACON m was not expressed. These studies assign a gene for human ACON m to chromosome 22, and are consistent with prior gene-mapping results.
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This study was supported in part by Grants HD-04612 and HD-05615 from the National Institute of Child Health and Human Development.
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Sparkes, R.S., Mohandas, T., Sparkes, M.C. et al. Aconitase (E.C. 4.2.1.3) mitochondrial locus mapped to human chromosome 22: Studies with Chinese hamster-human somatic cell hybrids. Biochem Genet 16, 751–756 (1978). https://doi.org/10.1007/BF00484732
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DOI: https://doi.org/10.1007/BF00484732