Abstract
The reaction of o-substituted aromatic amines with methacrylic acid gave N-aryl-α-methyl-Β-alanines, which were converted to dihydro-2,4-pyrimidinedione and dihydro-4-pyrimidinone-2-thione derivatives. The alkylation, acylation, and oximation of the dihydro-2,4-pyrimidinediones were accomplished. Conformational analysis of the compounds obtained was carried out by dynamic NMR methods.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1240–1247, September, 1991.
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Mitskyavichyus, V.Y., Baltrushis, R.S., Bilinskaite, I.C. et al. Synthesis and structure of 5-methyl-1-(2-R-phenyl)-dihydro-2,4(1H,3H)-pyrimidinediones and their 2-thiono analogs. Chem Heterocycl Compd 27, 999–1006 (1991). https://doi.org/10.1007/BF00484366
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DOI: https://doi.org/10.1007/BF00484366