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An investigation of the homology of guanylate kinase isozymes in mammals and further evidence for multiple GUK gene loci

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Abstract

Guanylate kinase in the red cells of 63 different mammalian species was studied by electrophoresis and multiple molecular forms of the enzyme were found in all species. Two species were investigated in more detail. Using molecular weight estimates as a criterion of homology, the fallow deer and the Chinese hamster were found to have isozymes that corresponded to isozymes e, f, and g of man. Variation in the guanylate kinase isozymes was detected in a small population of orangutans. Results suggested that isozymes a and b were monomeric and that they were the products of a gene locus, GUK 1 , different from the locus GUK 3 which coded for isozymes e, f, and g. Products c and d of the presumptive GUK 2 locus were not found in the orangutan.

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Authors and Affiliations

  1. MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, England

    Talat Jamil & Rachel A. Fisher

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  1. Talat Jamil
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  2. Rachel A. Fisher
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Jamil, T., Fisher, R.A. An investigation of the homology of guanylate kinase isozymes in mammals and further evidence for multiple GUK gene loci. Biochem Genet 15, 847–858 (1977). https://doi.org/10.1007/BF00483981

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  • DOI: https://doi.org/10.1007/BF00483981

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