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Analogs of pyrimidine nucleosides

IX. N1-dihydroxyalkyl derivatives of cytosine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

α-(1-Cytosinyl)-γ-butyrolactone was obtained by condensation of bis(trimethylsilyl)cytosine with α-bromobutyrolactone. The reduction of α-(1-cytosinyl)-γ-butyrolactone with sodium borohydride gave N1-(1,4-dihydroxy-2-butyl)cytosine, the acylation of which with benzoyl chloride and subsequent partial hydrolysis gave N1-(1,4-dihydroxy-2-butyl)-N4-benzoylcytosine.

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See [1] for communication VIII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 694–698, May, 1975

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Giller, S.A., Zhuk, R.A., Berzinya, A.É. et al. Analogs of pyrimidine nucleosides. Chem Heterocycl Compd 11, 603–606 (1975). https://doi.org/10.1007/BF00480489

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  • DOI: https://doi.org/10.1007/BF00480489

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