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Gas-chromatographische Trennung tricyclischer Antidepressiva und ihrer Metabolite an Quarzcapillarsäulen

Separation of tricyclic antidepressants and their metabolites using fused silica capillary columns gas-liquid chromatography

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Summary

The selective gas-liquid chromatographic determination of the tricyclic antidepressants Imipramine, Clomipramine, Amitriptyline, Trimipramine, Doxepine, Protriptyline, Noxiptyline, Dibenzepine, Melitracene, Dimetacrine, Maprotiline, Mianserine, Nomifensine, Amoxapine, Loxapine and their metabolites in fused silica capillary columns using a thermoionic detector is described. A good separation was achieved using a column of cross-linked OV 1. The correlation coefficient of the standard ordinates in the region from 1–50 ng was between r = 0.9994 and 0.9999. The detection limit is within the lower therapeutic dosage values.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie der Westfälischen Wilhelms-Universität, Hittorfstrasse 58, D-4400, Münster, Bundesrepublik Deutschland

    L. Wedy & G. Blaschke

  2. Institut für Rechtsmedizin der Westfälischen Wilhelms-Universität, von-Esmarch-Strasse 86, D-4400, Münster, Bundesrepublik Deutschland

    G. Bohn

Authors
  1. L. Wedy
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  2. G. Bohn
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  3. G. Blaschke
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Additional information

Teil der Dissertation von L. Wedy, Universität Münster 1986

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Wedy, L., Bohn, G. & Blaschke, G. Gas-chromatographische Trennung tricyclischer Antidepressiva und ihrer Metabolite an Quarzcapillarsäulen. Z. Anal. Chem. 329, 466–467 (1987). https://doi.org/10.1007/BF00480088

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  • DOI: https://doi.org/10.1007/BF00480088

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