Abstract
Eighteen new derivatives of rhodanine were obtained by the reaction of 3-β-carboxyethylrhodanine with various oxo-compounds. The condensation proceeded fairly readily in glacial acetic acid with enanthaldehyde, acetal, diacetyl, pyruvic acid, furfural, anthraquinone, β-chloroanthraquinone, isatin, 5-bromoisatin, acenaphthenequinone, isobutyraldehyde, cyclopentanone, and cyclohexanone. The condensations with acetone, ethyl methyl ketone, acetoacetic ester, acetophenone, and 2-acetylnaphthalene were carried out by heating in ammoniacal solution.
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References
B. M. Turkevich, Collection III, The Synthesis of Naturally-Occurring Compounds, and Their Analogs and Fragments [in Russian], ZhOKh., 35, 205, 1965.
N. M. Turkevich and M. I. Ganitkevich, ZhOKh, 29, 1699, 1959.
M. Girard, Ann. Chim., 16, 326, 1941.
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For part II see [1].
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Turkevich, B.M. The synthesis of rhodanines with possible antimetabolic activity. Chem Heterocycl Compd 2, 535–537 (1966). https://doi.org/10.1007/BF00477513
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DOI: https://doi.org/10.1007/BF00477513